Technology Process of Lucidone
There total 10 articles about Lucidone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium methylate;
In
benzene;
for 1.5h;
Heating;
other solvent: methanol;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 57 percent / Me3SiOTf / CH2Cl2 / -78 - 20 °C
2: 66 percent / K2CO3 / acetone / 20 °C
3: 95 percent / Et3N / diethyl ether / 0 - 20 °C
4: 79 percent / TiCl4 / CH2Cl2 / -78 - 20 °C
5: 74 percent / TFA / CH2Cl2 / 20 °C
6: NaOMe / methanol
With
trimethylsilyl trifluoromethanesulfonate; sodium methylate; titanium tetrachloride; potassium carbonate; triethylamine; trifluoroacetic acid;
In
methanol; diethyl ether; dichloromethane; acetone;
DOI:10.1055/s-2005-864803
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 79 percent / TiCl4 / CH2Cl2 / -78 - 20 °C
2: 74 percent / TFA / CH2Cl2 / 20 °C
3: NaOMe / methanol
With
sodium methylate; titanium tetrachloride; trifluoroacetic acid;
In
methanol; dichloromethane;
DOI:10.1055/s-2005-864803
