ETHYL HIPPURATE

Base Information

• Chemical Name: ETHYL HIPPURATE
• CAS No.: 1499-53-2
• Molecular Formula: C11H13 N O3
• Molecular Weight: 207.229
• Hs Code.: 2924299090
• Mol file: 1499-53-2.mol

Synonyms:Hippuricacid, ethyl ester (6CI,7CI,8CI); Benzoylglycine ethyl ester; EthylN-benzoylglycinate; Ethyl benzamidoacetate; Ethyl benzoylglycinate; Ethylhippurate; N-Benzoylglycine ethyl ester; NSC 17140; NSC 17495

Chemical Property of ETHYL HIPPURATE

Chemical Property:

• Vapor Pressure: 2.52E-06mmHg at 25°C
• Melting Point: 58-60°C
• Boiling Point: 391.1°Cat760mmHg
• PKA: 13.14±0.46(Predicted)
• Flash Point: 190.3°C
• PSA: 55.40000
• Density: 1.133g/cm³
• LogP: 1.37040

Purity/Quality:

99% ^*data from raw suppliers

Ethyl 2-(benzoylamino)acetate ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Ethyl hippurate is a useful building block and reactant, and has been used in several catalytic reactions such as the ruthenium-catalyzed protodecarbonylation of N-substituted phthalimide derivatives, and the copper-catalyzed synthesis of imides.

Technology Process of ETHYL HIPPURATE

There total 88 articles about ETHYL HIPPURATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

glycine ethyl ester hydrochloride (623-33-6) + benzoyl chloride (98-88-4) → ethyl hippurate (1499-53-2)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 1h;

DOI:10.1055/s-1994-25715

Reference yield: 97.6%

benzoyl chloride (98-88-4) + GlyOEt*HCl (459-73-4) → ethyl hippurate (1499-53-2)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1039/c8md00139a

Reference yield: 97.0%

Hippuric Acid (495-69-2,140480-84-8,21251-67-2,91787-63-2,66407-11-2) + ethanol (64-17-5) → ethyl hippurate (1499-53-2)

Guidance literature:

With chloro-trimethyl-silane; at 22 ℃; for 40h;

DOI:10.1055/s-1983-30279

upstream raw materials:

1,4-dioxane

Hippuric Acid

chloroformic acid ethyl ester

triethylamine

Downstream raw materials:

N-(3-oxo-5,6-diphenyl-2,3-dihydro-pyridazin-4-yl)-benzamide

N-2-(2-hydroxyethylamino)-2-oxoethylbenzamide

hyppuroylurea

2-benzoylamino-3-oxo-propionic acid ethyl ester

Refernces

• 1、 Xu-Xu, Qing-Feng,Nishii, Yuji,Uetake, Yuta,Sakurai, Hidehiro,Miura, Masahiro. "Synthesis of Benzoisoselenazolones via Rh(III)-Catalyzed Direct Annulative Selenation by Using Elemental Selenium". supporting information. p. 17952 - 17959. Retrieved 2021/11/16.
• 2、 Chen, Yanchi,Gong, Hegui,Guo, Jiandong,Tao, Xianghua,Wang, Xiaotai. "Preparation of α-amino acids: via Ni-catalyzed reductive vinylation and arylation of α-pivaloyloxy glycine". . p. 220 - 226. Retrieved 2021/01/14.