phenyl(1H-pyrrolo[2,3-b]pyridin-4-yl)methanol

Base Information

• Chemical Name: phenyl(1H-pyrrolo[2,3-b]pyridin-4-yl)methanol
• CAS No.: 1067887-43-7
• Molecular Formula: C₁₄H₁₂N₂O
• Molecular Weight: 224.262
• Mol file: 1067887-43-7.mol

Synonyms:phenyl(1H-pyrrolo[2,3-b]pyridin-4-yl)methanol

Chemical Property of phenyl(1H-pyrrolo[2,3-b]pyridin-4-yl)methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of phenyl(1H-pyrrolo[2,3-b]pyridin-4-yl)methanol

There total 2 articles about phenyl(1H-pyrrolo[2,3-b]pyridin-4-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

1H-pyrrolo[2,3-b]pyridine-4-carbonitrile (344327-11-3) + benzaldehyde (100-52-7) → phenyl(1H-pyrrolo[2,3-b]pyridin-4-yl)methanol (1067887-43-7)

Guidance literature:

With fac-tris(2-phenylpyridinato-N,C₂')iridium(III); N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 20 ℃; for 12h; Irradiation; Inert atmosphere; Sealed tube;

DOI:10.1016/S1872-2067(17)62896-1

Reference yield: 73.0%

benzaldehyde (100-52-7) + 4-bromo-7-azaindole (348640-06-2) → phenyl(1H-pyrrolo[2,3-b]pyridin-4-yl)methanol (1067887-43-7)

Guidance literature:

4-bromo-7-azaindole; With methyllithium; In tetrahydrofuran; diethyl ether; at -78 ℃; for 0.333333h;

With tert.-butyl lithium; In tetrahydrofuran; diethyl ether; pentane; at -78 ℃; for 0.25h;

benzaldehyde; In tetrahydrofuran; diethyl ether; pentane; at -78 - 20 ℃;

DOI:10.1055/s-2008-1067103

Reference yield: 53.0%

phenyl(1H-pyrrolo[2,3-b]pyridin-4-yl)methanol (1067887-43-7) → phenyl(1H-pyrrolo[2,3-b]pyridin-4-yl)methanone

Guidance literature:

With chromium(VI) oxide; tert.-butylhydroperoxide; In dichloromethane; water; at 20 ℃; for 24h;

DOI:10.1055/s-2008-1067103

upstream raw materials:

benzaldehyde

4-bromo-7-azaindole

1H-pyrrolo[2,3-b]pyridine-4-carbonitrile

Refernces

• 1、 Pillard, Christelle,Bassene, Carine Ekambome,Suzenet, Franck,Guillaumet, Gerald. "Synthesis of 4-, 5- and 6-benzoylated 7-azaindoles". experimental part. p. 2049 - 2054. Retrieved 2009/04/03.