6-Bromoindanone

Base Information

• Chemical Name: 6-Bromoindanone
• CAS No.: 14548-39-1
• Molecular Formula: C9H7BrO
• Molecular Weight: 211.058
• Hs Code.: 29147000
• Mol file: 14548-39-1.mol

Synonyms:1-Indanone,6-bromo- (6CI,7CI,8CI);6-Bromo-1-indanone;6-Bromo-2,3-dihydro-1H-inden-1-one;

Chemical Property of 6-Bromoindanone

Chemical Property:

• Appearance/Colour: White to yellow crystalline powder or needles
• Vapor Pressure: 0.002mmHg at 25°C
• Melting Point: 111-115 ºC
• Refractive Index: 1.623
• Boiling Point: 291.6 ºC at 760 mmHg
• Flash Point: 111.6 ºC
• PSA: 17.07000
• Density: 1.608 g/cm³
• LogP: 2.57800
• Storage Temp.: Refrigerator

Purity/Quality:

99% ^*data from raw suppliers

6-Bromo-1-indanone >98.0%(GC) ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-Bromo-1-indanone is used as an organic chemical synthesis intermediate.

Technology Process of 6-Bromoindanone

There total 30 articles about 6-Bromoindanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-(4-bromophenyl)propionic acid (1643-30-7) → 6-bromoindan-1-one (14548-39-1)

Guidance literature:

With trifluorormethanesulfonic acid; In dichloromethane; at 80 ℃; for 1h; High pressure; Inert atmosphere; Green chemistry;

DOI:10.3390/molecules19055599

Reference yield: 98.0%

6-hydroxy-1-indanone (62803-47-8) + tert-butyldimethylsilyl chloride (18162-48-6) → 6-bromoindan-1-one (14548-39-1)

Guidance literature:

With 1H-imidazole; In dichloromethane;

DOI:10.1002/cphc.201900917

Reference yield: 91.0%

3-(4-bromophenyl)propanoyl chloride (55394-81-5) → 6-bromoindan-1-one (14548-39-1)

Guidance literature:

With aluminium trichloride; In carbon disulfide;

DOI:10.1021/jo00196a024

upstream raw materials:

3-(4-bromophenyl)propionic acid

3-(4-bromophenyl)propanoyl chloride

inden-1-one

sulfuric acid

Downstream raw materials:

6-phenylindan-1-one

6-bromo-2,3-dihydro-1,1-dimethyl-1H-indene

1-oxo-6-indanecarbonitrile

C₁₆H₁₃BrO₂

Refernces

• 1、 Huang, Mingqin,Duan, Shengzu,Ma, Xueqiong,Cai, Bicheng,Wu, Dongmei,Li, Yan,Li, Liang,Zhang, Hongbin,Yang, Xiaodong. "Synthesis and antitumor activity of aza-brazilan derivatives containing imidazolium salt pharmacophores". . p. 1027 - 1036. Retrieved 2019/06/27.
• 2、 Duan, Ya-Nan,Cui, Li-Qian,Zuo, Lin-Hong,Zhang, Chi. "Recyclable Hypervalent-Iodine-Mediated Dehydrogenative α,β′-Bifunctionalization of β-Keto Esters under Metal-Free Conditions". . p. 13052 - 13057. Retrieved 2015/09/07.