C₁₂H₁₆BrNO

Base Information

• Chemical Name: C₁₂H₁₆BrNO
• CAS No.: 1357258-89-9
• Molecular Formula: C₁₂H₁₆BrNO
• Molecular Weight: 270.169
• Mol file: 1357258-89-9.mol

Synonyms:C₁₂H₁₆BrNO

Chemical Property of C₁₂H₁₆BrNO

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of C₁₂H₁₆BrNO

There total 2 articles about C₁₂H₁₆BrNO which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromo-2-methylbenzoyl?chloride (21900-41-4) + diethylamine (109-89-7) → C12H16BrNO (1357258-89-9)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 1h;

Reference yield:

5-bromo-2-methylbenzoic acid (79669-49-1) → C12H16BrNO (1357258-89-9)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 0.5 h / 20 °C

2: sodium hydroxide / water; tetrahydrofuran / 1 h / 20 °C

With oxalyl dichloride; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield: 72.0%

(S)-tert-butyl 2-(5-(6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)naphthalen-2-yl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate (1228552-26-8) + C12H16BrNO (1357258-89-9) → C34H40N4O3 (1357258-91-3)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene; at 90 ℃; for 10h; Inert atmosphere;

upstream raw materials:

5-bromo-2-methylbenzoyl?chloride

diethylamine

5-bromo-2-methylbenzoic acid

Downstream raw materials:

C₃₄H₄₀N₄O₃

Refernces