2-Ethoxypyrazine

Base Information

• Chemical Name: 2-Ethoxypyrazine
• CAS No.: 38028-67-0
• Molecular Formula: C6H8 N2 O
• Molecular Weight: 124.142
• Hs Code.: 2933990090
• European Community (EC) Number: 253-750-8
• DSSTox Substance ID: DTXSID10878914
• Nikkaji Number: J261.286K
• Wikidata: Q72472031
• ChEMBL ID: CHEMBL93554
• Mol file: 38028-67-0.mol

Synonyms:2-Ethoxypyrazine;38028-67-0;Pyrazine, ethoxy-;2-Ethoxy pyrazine;Ethoxypyrazine;Pyrazine, 2-ethoxy-;3-ethoxypyrazine;2-Ethoxy-pyrazine;2-Ethoxypyrazine, AldrichCPR;CHEMBL93554;SCHEMBL1692005;DTXSID10878914;AC1594;MFCD00014609;AKOS006222051;CS-W013527;AC-16589;AM20070349;E0697;FT-0612223;EN300-7370787;A823965;Q-100445

Chemical Property of 2-Ethoxypyrazine

Chemical Property:

• Vapor Pressure: 1.89mmHg at 25°C
• Refractive Index: 1.4997
• Boiling Point: 92 °C / 90mmHg
• PKA: 0.68±0.10(Predicted)
• Flash Point: 59.8oC
• PSA: 35.01000
• Density: 1.07
• LogP: 0.87530
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 124.063662883
• Heavy Atom Count: 9
• Complexity: 77.5

Purity/Quality:

99% ^*data from raw suppliers

2-Ethoxypyrazine >98.0%(GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36-37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=NC=CN=C1

Technology Process of 2-Ethoxypyrazine

There total 3 articles about 2-Ethoxypyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2-chloropyrazin (14508-49-7) + ethanol (64-17-5) → 2-ethoxypyrazine (38028-67-0)

Guidance literature:

With sodium; Heating;

DOI:10.1039/P29860001255

Reference yield: 68.0%

2-chloropyrazin (14508-49-7) + sodium ethanolate (141-52-6) → 2-ethoxypyrazine (38028-67-0)

Guidance literature:

In 1-methyl-pyrrolidin-2-one; at 90 ℃; for 0.0125h; microwave irradiation;

DOI:10.1016/S0040-4020(01)01182-6

Reference yield:

→ 2-ethoxypyrazine (38028-67-0)

Guidance literature:

(yield)77percent;

DOI:10.1021/jo01032a035

upstream raw materials:

2-chloropyrazin

sodium ethanolate

ethanol

Downstream raw materials:

pyrazin-2(1H)-one

Refernces

• 1、 Al-Awadi, Nouria,Taylor, Roger. "The Mechanism of Thermal Eliminations. Part 18. Relative Rates of Pyrolysis of 2-Ethoxypyrazine, 3-Ethoxypyridazine, 2-and 4-Ethoxypyrimidine, 3-Chloro-6-ethoxypyridazine, and 2-Chloro-4-ethoxypyrimidine : the Effect of the Aza 'Substituent' and ?-Bond Order on the Elimination Rate". . p. 1255 - 1258. Retrieved 2007/10/02.