Pyrazine-2-carbohydrazide

Base Information

• Chemical Name: Pyrazine-2-carbohydrazide
• CAS No.: 768-05-8
• Molecular Formula: C5H6N4O
• Molecular Weight: 138.129
• Hs Code.: 2933990090
• European Community (EC) Number: 872-028-9
• NSC Number: 88100
• UNII: V9GFH1A08Z
• DSSTox Substance ID: DTXSID90227608
• Nikkaji Number: J3.087.337H
• Wikidata: Q72503358
• ChEMBL ID: CHEMBL125613
• Mol file: 768-05-8.mol

Synonyms:pyrazine-2-carboxylic acid hydrazide

Chemical Property of Pyrazine-2-carbohydrazide

Chemical Property:

• Melting Point: 169 °C
• Refractive Index: 1.591
• PKA: 10.07±0.10(Predicted)
• PSA: 80.90000
• Density: 1.335g/cm³
• LogP: 0.17130
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: -0.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 138.05416083
• Heavy Atom Count: 10
• Complexity: 127

Purity/Quality:

98%,99%, ^*data from raw suppliers

Pyrazine-2-carbohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=C(C=N1)C(=O)NN

Technology Process of Pyrazine-2-carbohydrazide

There total 11 articles about Pyrazine-2-carbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl pyrazine-2-carboxylate (6164-79-0) → pyrazine-2-carbohydrazide (768-05-8)

Guidance literature:

With hydrazine; In ethanol; for 2h; Heating / reflux;

Reference yield: 95.0%

ethyl 2-pyrazinecarboxylate (6924-68-1) → pyrazine-2-carbohydrazide (768-05-8)

Guidance literature:

With hydrazine hydrate; In ethanol; for 6h; Reflux;

DOI:10.1007/s00044-014-1314-4

Reference yield: 87.0%

pyrazinoyl chloride (19847-10-0) → pyrazine-2-carbohydrazide (768-05-8)

Guidance literature:

With hydrazine; In dichloromethane; for 2h; Heating;

upstream raw materials:

methyl pyrazine-2-carboxylate

pyrazinoyl chloride

ethyl 2-pyrazinecarboxylate

pyrazinecarboxylic acid imidazolide

Downstream raw materials:

N'-[(1E)-(2-hydroxyphenyl)methylidene]pyrazine-2-carbohydrazide

N-benzenesulfonyl-N'-pyrazinecarbonyl-hydrazine

(4-chlorobenzylidene)pyrazine-2-carboxylic acid hydrazide

[1-(4-bromophenyl)ethylidene]pyrazine-2-carboxylic acid hydrazide

Refernces

• 1、 Tian, Haiquan,Ungur, Liviu,Zhao, Lang,Ding, Shuai,Tang, Jinkui,Chibotaru, Liviu F.. "Exchange Interactions Switch Tunneling: A Comparative Experimental and Theoretical Study on Relaxation Dynamics by Targeted Metal Ion Replacement". . p. 9928 - 9939. Retrieved 2018.
• 2、 Sharma, Bharvi,Kumar, Sumit,Preeti,Johansen, Matt D.,Kremer, Laurent,Kumar, Vipan. "1H-1,2,3-triazole embedded Isatin-Benzaldehyde-bis(heteronuclearhydrazones): design, synthesis, antimycobacterial, and cytotoxic evaluation". . p. 301 - 307. Retrieved 2021/12/09.
• 3、 Maldonado, Yndira Dolores,Scalese, Gonzalo,Manieri, Karyn Fernanda,Pavan, Fernando R.,Aguirre Méndez, Larry D.,Gambino, Dinorah. "New silver(I) phosphino complexes: Evaluation of their potential as prospective agents against Mycobacterium tuberculosis". . . Retrieved 2021/12/14.