Leucogen

Base Information

• Chemical Name: Leucogen
• CAS No.: 1950-36-3
• Molecular Formula: C₁₄H₁₇NO₄S
• Molecular Weight: 295.359
• NSC Number: 400257
• UNII: 5ZB58O726V
• DSSTox Substance ID: DTXSID20941264
• Nikkaji Number: J22.682C
• Wikidata: Q27263098
• Mol file: 1950-36-3.mol

Synonyms:ethyl-4-carboxy alpha-phenyl-1,2-thiazolidine acetate;leucogen;Leukogen;Leyk

Chemical Property of Leucogen

Chemical Property:

• Vapor Pressure: 5.28E-10mmHg at 25°C
• Refractive Index: 1.582
• Boiling Point: 479.492 °C at 760 mmHg
• Flash Point: 243.788 °C
• PSA: 100.93000
• Density: 1.292 g/cm³
• LogP: 1.77780
• XLogP3: -0.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 6
• Exact Mass: 295.08782920
• Heavy Atom Count: 20
• Complexity: 357

Purity/Quality:

99% ^*data from raw suppliers

Leucogen ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C(C1NC(CS1)C(=O)O)C2=CC=CC=C2
• Recent ClinicalTrials: A Multi-center, Randomized, Double-blind, Phase III Clinical Trial of Leucogen Versus Placebo on Leukocyte and Platelet Whole-course Management Assisted by PFLL Chemotherapy in the Treatment of Stage IV, Recurrent or Metastatic NPC

Technology Process of Leucogen

There total 5 articles about Leucogen which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

l-cysteine hydrochloride (52-89-1) + ethyl 3-oxo-2-phenylpropanoate (17838-69-6) → (2Ξ,4R)-2-((Ξ)-ethoxycarbonyl-phenyl-methyl)-thiazolidine-4-carboxylic acid (1950-36-3)

Guidance literature:

With water;

Reference yield:

ethyl 3-oxo-2-phenylpropanoate (17838-69-6) → leucogen (1950-36-3)

Guidance literature:

Multi-step reaction with 3 steps

3: aqueous NaHCO₃

With sodium hydrogencarbonate;

Reference yield:

S-(2-ethoxycarbonyl-2-phenyl-vinyl)-DL-cysteine (832733-03-6) → leucogen (1950-36-3)

Guidance literature:

With sodium hydrogencarbonate;

upstream raw materials:

S-(2-ethoxycarbonyl-2-phenyl-vinyl)-DL-cysteine

ethyl α-(methoxymethylene)phenylacetate

ethyl 3-oxo-2-phenylpropanoate

l-cysteine hydrochloride

Downstream raw materials:

(Ξ)-((2Ξ,4R)-4-carboxy-thiazolidin-2-yl)-phenyl-acetic acid