Chlorotetracycline

Base Information

• Chemical Name: Chlorotetracycline
• CAS No.: 57-62-5
• Molecular Formula: C22H23ClN2O8
• Molecular Weight: 478.886
• Mol file: 57-62-5.mol

Synonyms:2-Naphthacenecarboxamide,7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-(7CI,8CI);2-Naphthacenecarboxamide,7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-,[4S-(4a,4aa,5aa,6b,12aa)]-;Aureomicina;Aureomycin;Aureomykoin;Aurofac;Aureocina;A-Mycin;Acronize;7-Chlorotetracycline;7-Chlortetracycline;Tri-chlortetracycline;Acronize PD;Chrysomykine;Chlortetracycline;Centraureo;Chlorocyclinum;

Chemical Property of Chlorotetracycline

Chemical Property:

• Appearance/Colour: Golden yellow crystal powder
• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 168.5oC
• Refractive Index: 1.745
• Boiling Point: 821.078 °C at 760 mmHg
• PKA: pKa 3.3 (Uncertain)
• Flash Point: 450.372 °C
• PSA: 181.62000
• Density: 1.7 g/cm³
• LogP: 1.13930
• Storage Temp.: 2-8°C
• Water Solubility.: 0.63g/L(25 oC)

Purity/Quality:

99% ^*data from raw suppliers

Chlortetracycline Selective Supplement suitableformicrobiology ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Description: Chlortetracycline (Brand name: Aureomycin) is the 7-chloro substitution derivative of the tetracycline and has a golden color. As a veterinary medicine, chlortetracycline is commonly used for the treatment of conjunctivitis of cats. It can also be used in the treatment of infections occurring in the urinary tract, respiratory tract, and the intestines. Its mechanism of action is through inhibiting the protein synthesis, inhibiting the binding of aminoacyl-tRNA to the mRNA-ribosome complex through binding to the 30S ribosome subunit.
• Uses: Chlortetracycline was the first reported member of the tetracycline class, isolated from Streptomyces aureofaciens in 1948. Chlortetracyclines heralded the early wave of antibiotic discoveries from microbes and after 50 years are still widely used as pharmaceuticals. Chlortetracycline is a pigment and, like most pigments, is extremely sensitive to environmental and storage conditions. Commercial chlortetracycline may contain significant levels of degradation products.
• Indications: Chlorotetracycline, an antibiotic with a broad spectrum of action, causes a bacteriostatic effect with respect to Gram-positive (staphylococci, including those that produce penicillinase; streptococci, pneumococci; clostridia, listeria, and anthrax bacillus) and Gram-negative microorganisms (gonococci, whooping cough bacillus, colon bacillus, enterobacteria, klebisella, salmonella, shigella), as well as Rickettsia, chlamydia, mycoplasma, and spirochaeta. Blue-pus bacillus, proteus, serracia, most strains of Bacteroides fragilis, most fungi, and small viruses are resistant to this drug. It is used for pneumonia, bronchitis, empyema of the lungs, angina, cholecystitis, whooping cough, endocarditis, endometritis, intestinal infections, prostatitis, syphilis, gonorrhea, brucellosis, osteomyelitis, purulent infections of soft tissues, and others caused by microorganisms sensitive to this drug. Synonyms of this drug are aureomycin, biomycin, xanthomycin, and others.
• Therapeutic Function: Antibacterial
• Clinical Use: Its uses are those common to the group. It has also been used topically in the management of recurrent aphthous ulcers of the mouth, but experience is limited and the mechanism of action is unknown.

Technology Process of Chlorotetracycline

There total 5 articles about Chlorotetracycline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + 4-epi chlortetracycline (14297-93-9) → Chlortetracycline (57-62-5)

Guidance literature:

Gleichgeweicht;

DOI:10.1021/ja01568a050

Reference yield:

→ Chlortetracycline (57-62-5)

Guidance literature:

Herstellung von <³⁶Cl>Chlortetracyclin;

DOI:10.1021/ja01521a040

Reference yield:

→ Epichlortetracyclin (57-62-5,14297-93-9,28129-76-2)

Guidance literature:

Chlortetracyclin, NaH2PO4;

upstream raw materials:

methanol

4-epi chlortetracycline

Downstream raw materials:

isochlortetracycline

(S)-4-((1S)-4-carbamoyl-2t-dimethylamino-3,6ξ-dihydroxy-5-oxo-cyclohex3-en-r-yl)-3-((S)-7-chloro-4-hydroxy-1-methyl-3-oxo-phthalan-1-yl)-butyric acid

4-methoxyphthalic acid

TETRACYCLINE

Refernces

• 1、 -. "Compositions and methods for treating hemorrhagic virus infections and other disorders". . . Retrieved 2008/06/13.