2-Chloro-N,N-dimethylethanamine hydrochloride

Base Information

• Chemical Name: 2-Chloro-N,N-dimethylethanamine hydrochloride
• CAS No.: 4584-46-7
• Molecular Formula: C4H10ClN^.HCl
• Molecular Weight: 144.044
• Hs Code.: 29211980
• European Community (EC) Number: 224-970-1
• UNII: HE7Z9G0YMA
• ChEMBL ID: CHEMBL3561603
• DSSTox Substance ID: DTXSID7052109
• NSC Number: 111230,1917
• Wikidata: Q27147655
• Mol file: 4584-46-7.mol

Synonyms:4584-46-7;2-Dimethylaminoethyl chloride hydrochloride;2-Chloro-N,N-dimethylethanamine hydrochloride;2-Chloro-N,N-dimethylethylamine hydrochloride;2-Chloroethyldimethylamine hydrochloride;2-(Dimethylamino)ethyl chloride hydrochloride;(2-Chloroethyl)dimethylamine hydrochloride;2-Dimethylaminoethyl chloride, HCl;N,N-Dimethylaminoethyl chloride hydrochloride;N,N-Dimethyl-2-chloroethylamine hydrochloride;Dimethylaminoethyl chloride hydrochloride;MFCD00012516;Ethanamine, 2-chloro-N,N-dimethyl-, hydrochloride;N-(2-chloroethyl)-N,N-dimethylamine hydrochloride;2-Dimethylaminochloroethane hydrochloride;1-Chloro-2-dimethylaminoethane hydrochloride;N-(2-Chloroethyl)dimethylamine hydrochloride;2-chloro-N,N-dimethylethanamine;hydrochloride;DTXSID7052109;2-dimethylaminoethyl chloride HCl;N,N-Dimethyl-N-(2-chloroethyl)amine hydrochloride;NSC-111230;2-Chloro-N,N-dimethyl-ethan Amine-d4 Hydrochloride;2-chloro-N,N-dimethylethanaminium chloride;2-Chloro-N,N-dimethylethylamine-d6Hydrochloride;2-Chloroethyl dimethyl ammonium chloride;Chloro(dimethylamino)ethane hydrochloride;Dimethyl(2-chloroethyl)amine hydrochloride;HE7Z9G0YMA;(2-Chloroethyl)dimethylamine monohydrochloride;1-Chloro-2-(dimethylamino)ethane hydrochloride;2-chloro-N,N-dimethyl-ethanamine Hydrochloride;(Chloroethyl)dimethylamine hydrochloride;NSC-1917;(.beta.-Chloroethyl)dimethylamine hydrochloride;.beta.-Dimethylaminoethyl chloride hydrochloride;2-(N, N-dimethylamino)ethyl chloride, hydrochloride;2-(N,N-dimethylamino)ethyl chloride, hydrochloride;2-[N, N-dimethylamino]ethyl chloride, hydrochloride;2-[N,N-dimethylamino]ethyl chloride, hydrochloride;2-(Dimethylamino)ethylchloride hydrochloride;beta-CHLOROETHYLDIMETHYLAMINE HCl;chloroethyldimethylamine HCl;SCHEMBL9244;dimethylaminoethyl chloride HCl;CHEMBL3561603;DTXCID9030678;CHEBI:78153;2-dimethylaminoethyl chloride.HCl;NSC1917;LQLJZSJKRYTKTP-UHFFFAOYSA-N;BCP22799;CS-M3173;chloroethyldimethylamine hydrochloride;Tox21_303802;2-chloro-N,N-dimethylethanamine HCl;2-dimethylaminoethylchloride HCl salt;NSC111230;N,N-dimethylamino-2-chloroethane-HCl;AKOS008030282;dimethylaminoethylchloride hydrochloride;BCP9000105;2-DimethylaminoEthylchloridehydrochloride;2-chloroethyl-dimethylamine hydrochloride;2-dimethylaminoethylchloride-hydrochloride;NCGC00357086-01;2 -chloroethyl-dimethylamine hydrochloride;2-Dimethylaminoethylchloride hydrochloride;(2-chloro-ethyl)-dimethyl-amine HCl salt;.BETA.-CHLOROETHYLDIMETHYLAMINE HCL;2-dimethylaminoethyl-chloride hydrochloride;CAS-4584-46-7;(2-chloroethyl)-dimethylamine hydrochloride;2-chloroethyl-n,n-dimethylammonium chloride;2-dimethylamino ethyl chloride hydrochloride;2-dimethylamino-ethyl chloride hydrochloride;beta-dimethylaminoethylchloride hydrochloride;dimethyl-(2-chloroethyl)amine hydrochloride;N,N-dimethylaminoethylchloride hydrochloride;(2-chloro-ethyl)-dimethylamine hydrochloride;(2-chloroethyl)-dimethyl-amine hydrochloride;1-chloro-2-dimethlyaminoethane hydrochloride;2-(dimethylamino)-ethylchloride hydrochloride;2-(dimethylamino)ethyl chloride.hydrochloride;2-chloro-n,n-dimethylethylamin-hydrochloride;2-chloroethyl-dimethylamine hydrogen chloride;AM20100171;beta-dimethylaminoethyl chloride hydrochloride;dimethylaminoethyl chloride hydrochloride salt;dimethylaminoethyl hydrochloride hydrochloride;FT-0612181;FT-0664643;n,n-dimethyl-2-chlorethylamine hydrochloride;(2-chloro-ethyl)-dimethyl-amine hydrochloride;(2-chloro-ethyl)-dimethyl-amine-hydrochloride;(2-chloro-ethyl)-dimethyl-amine.hydrochloride;1-chloro-2-dimethylamino-ethane hydrochloride;2-(dimethyl amino)ethyl chloride hydrochloride;2-(dimethylamino)-ethyl chloride hydrochloride;2-(dimethylamino)-ethyl chloride-hydrochloride;2-chloro-N,N-dimethylethanamine.hydrochloride;2-chloroethyl dimethylamine hydrochloride salt;N,N-dimethyl-2-chloroethylamine-hydrochloride;N,N-dimethylamino-2-chloroethane hydrochloride;(N,N-dimethylamino)ethyl chloride hydrochloride;2-chloro ethyl dimethylamine hydrochloride salt;2-chloro-N,N-dimethylethane amine hydrochloride;2-dimethylaminoethylchloride, hydrochloride salt;D77997;n-(2-chlorethyl)-n,n-dimethylammonium chloride;2-(N,N-dimethylamino)ethylchloride hydrochloride;2-chloro-ethyl-dimethyl-amine hydrochloride salt;2-Chloro-N,N-dimethyl ethyl amine hydrochloride;(2-chloro-ethyl)-dimethyl-amine hydrogen chloride;1-chloro-2-(N,N-dimethylamino)ethane hydrochloride;2-Chloro-N,N-dimethylethylamine hydrochloride, 99%;J-509275;Q27147655;F0001-1241

Chemical Property of 2-Chloro-N,N-dimethylethanamine hydrochloride

Chemical Property:

• Appearance/Colour: colorless to beige crystal
• Vapor Pressure: 214mmHg at 25°C
• Melting Point: 201-204 °C(lit.)
• Boiling Point: 57.8 °C at 760 mmHg
• Flash Point: 21.6 °C
• PSA: 3.24000
• LogP: 1.58880
• Storage Temp.: Store below +30°C.
• Sensitive.: Hygroscopic
• Solubility.: 2000g/l
• Water Solubility.: 2000 g/L (20 ºC)
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 143.0268547
• Heavy Atom Count: 7
• Complexity: 28.7

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-N,N-dimethylethylamine hydrochloride 99% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T,N,T+
• Hazard Codes: T,N,T+
• Statements: 22-24-36/37/38-68-51/53-26
• Safety Statements: 26-36/37-45-61-36/37/39-28A

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)CCCl.Cl
• Uses: 2-Chloro-N,N-dimethylethylamine hydrochloride (DMC) is used as intermediate for the synthesis of pharmaceuticals (e.g. bephenium hydroxnaphthoate, diltiazem, mepyramine and phenyltoloxamine). Product Data Sheet 2-Chloro-N,N-dimethylethylamine is a widely used as a intermediate and starting reagent for organic synthesis. 2-Chloro-N,N-dimethylethylamine is a widely used as a intermediate and starting reagent for organic synthesis. Also acts as Intermediate for the syntheses of bephenium hydroxynaphthoate, diltiazem, mepyramine and phenyltoloxamine.

Technology Process of 2-Chloro-N,N-dimethylethanamine hydrochloride

There total 3 articles about 2-Chloro-N,N-dimethylethanamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(N,N-dimethylamino)ethanol (108-01-0) → (2-chloroethyl)dimethylamine hydrochloride (4584-46-7)

Guidance literature:

With thionyl chloride; In dichloromethane; at 0 - 20 ℃;

Reference yield: 60.8%

dimethyl amine (124-40-3) + 2-chloro-ethanol (107-07-3) → (2-chloroethyl)dimethylamine hydrochloride (4584-46-7)

Guidance literature:

dimethyl amine; 2-chloro-ethanol; for 4h; Reflux;

With thionyl chloride; In tetrachloromethane; at 20 ℃; for 4h; Cooling with ice;

Reference yield: 51.0%

→ (2-chloroethyl)dimethylamine hydrochloride (4584-46-7)

Guidance literature:

upstream raw materials:

2-(N,N-dimethylamino)ethanol

dimethyl amine

2-chloro-ethanol

Downstream raw materials:

4-(2-Dimethylamino-ethoxy)-3-methoxy-benzoic acid ethyl ester

7-chloro-1-(2-dimethylamino-ethyl)-5-phenyl-1,5-dihydro-benzo[e][1,4]thiazepin-2-one

N,N-dimethyl-2-(4'-phenylthiazol-2'-ylthio)ethylamine

7-(2-Dimethylaminoethoxy)-4-methylcoumarin

Refernces

• 1、 Babu, K. Naresh,Masarwa, Ahmad,Massarwe, Fedaa,Shioukhi, Israa. "Sequential Selective C?H and C(sp3)?+P Bond Functionalizations: An Entry to Bioactive Arylated Scaffolds". supporting information. p. 26199 - 26209. Retrieved 2021/11/09.
• 2、 Houston, Sevan D.,Fahrenhorst-Jones, Tyler,Xing, Hui,Chalmers, Benjamin A.,Sykes, Melissa L.,Stok, Jeanette E.,Farfan Soto, Clementina,Burns, Jed M.,Bernhardt, Paul V.,De Voss, James J.,Boyle, Glen M.,Smith, Maree T.,Tsanaktsidis, John,Savage, G. Paul,Avery, Vicky M.,Williams, Craig M.. "The cubane paradigm in bioactive molecule discovery: Further scope, limitations and the cyclooctatetraene complement". supporting information. p. 6790 - 6798. Retrieved 2019/07/22.