Creatine

Base Information Edit

Chemical Name:Creatine
CAS No.:57-00-1
Deprecated CAS:2087491-49-2
Molecular Formula:C4H9N3O2
Molecular Weight:131.134
Hs Code.:29252900
European Community (EC) Number:200-306-6
NSC Number:8752
UNII:MU72812GK0
DSSTox Substance ID:DTXSID1040451
Nikkaji Number:J9.321A
Wikipedia:Creatine
Wikidata:Q223600
NCI Thesaurus Code:C37937
RXCUI:2907
Metabolomics Workbench ID:37054
ChEMBL ID:CHEMBL283800
Mol file:57-00-1.mol

Synonyms:Creatine

Suppliers and Price of Creatine

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Creatine, anhydrous
100g
$ 279.00

TRC
Creatine
1g
$ 50.00

TCI Chemical
Creatine
100G
$ 38.00

TCI Chemical
Creatine
25G
$ 14.00

Sigma-Aldrich
Creatine anhydrous
100g
$ 134.00

Sigma-Aldrich
Creatine anhydrous
500g
$ 427.00

Sigma-Aldrich
Creatine United States Pharmacopeia (USP) Reference Standard
200 mg
$ 324.00

Sigma-Aldrich
Creatine anhydrous
50g
$ 73.40

Sigma-Aldrich
Creatine anhydrous
10mg
$ 24.40

CSNpharm
Creatine
250mg
$ 35.00

Total 171 raw suppliers

Chemical Property of Creatine Edit

Chemical Property:

Appearance/Colour:White powder
Vapor Pressure:0.00178mmHg at 25°C
Melting Point:~295°C (dec.)
Refractive Index:1.552
Boiling Point:271.6 °C at 760 mmHg
PKA:2.63(at 25℃)
Flash Point:118.1 °C
PSA：90.41000
Density:1.38 g/cm³
LogP:-0.30370
Storage Temp.:Store at RT.
Solubility.:Water (Slightly, Heated)
Water Solubility.:Soluble in water.
XLogP3:-1.2
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:131.069476538
Heavy Atom Count:9
Complexity:134

Purity/Quality:

99% ^*data from raw suppliers

Creatine, anhydrous ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36

MSDS Files:: SDS file from LookChem

Useful:

Chemical Classes:Biological Agents -> Amino Acids and Derivatives
Canonical SMILES:CN(CC(=O)O)C(=N)N
Recent ClinicalTrials:Creatine Supplementation in Autism Spectrum Disorder
Description Creatine (N-aminoiminomethyl-N-methyl glycine) is a naturally occurring and nitrogen-containing compound comprised from amino acids that is classified within the family of guanidine phosphagens. Creatine supplementation is one of the most studied and effective ergogenic aids for athletes. The ergogenic effects of creatine supplementation are well documented, with evidence supporting its efficacy in increasing muscle strength, lean mass, and exercise performance/muscle function, particularly when combined with exercise in different populations, from athletes to a wide spectrum of patient populations.
Uses and Mechanism of Action Creatine supplementation in vegetarians increased total creatine, creatine, and phosphocreatine concentrations in vastus lateralis and gastrocnemius muscle, plasma, and red blood cells, often to levels greater than omnivores. Creatine supplementation increased lean tissue mass, type II fiber area, insulin-like growth factor-1, muscular strength, muscular endurance, Wingate mean power output, and brain function (memory and intelligence) in vegetarian participants. Creatine mechanisms of action involve rapid energy provision by transferring the N-phosphoryl group from phosphorylcreatine (PCr) to adenosine diphosphate (ADP), thus resynthesizing adenosine triphosphate (ATP) and spatial energy buffering, transferring energy from the mitochondria to the cytosol. Creatine is synthesized endogenously from arginine and glycine by arginine glycine amidinotransferase (AGAT) to guanidinoacetate (GAA). The GAA is then methylated by the enzyme guanidinoacetate N-methyltransferase (GAMT) with S-adenosyl methionine (SAMe) to form creatine. The kidney, pancreas, liver, and some regions in the brain contain AGAT with most GAA formed in the kidney and converted by GMAT to creatine in the liver. Endogenous creatine synthesis provides about half of the daily need for creatine. The remaining amount of creatine needed to maintain normal tissue levels of creatine is obtained in the diet primarily from red meat and fish or dietary supplements. Brain creatine content has been suggested to be affected by other factors, such as aging.

Technology Process of Creatine

There total 38 articles about Creatine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%