Boc-Asn(Trt)-OH

Base Information

• Chemical Name: Boc-Asn(Trt)-OH
• CAS No.: 132388-68-2
• Molecular Formula: C28H30N2O5
• Molecular Weight: 474.557
• Hs Code.: 2924 29 70
• DSSTox Substance ID: DTXSID90464258
• Mol file: 132388-68-2.mol

Synonyms:Boc-Asn(Trt)-OH;132388-68-2;Boc-N-beta-Trityl-L-asparagine;N2-(tert-Butoxycarbonyl)-N4-trityl-L-asparagine;Nalpha-Boc-Ngamma-trityl-L-asparagine;(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-4-oxo-4-(tritylamino)butanoic acid;Nalpha-tert-Butoxycarbonyl-Ngamma-trityl-L-asparagine;Boc-Ngamma-trityl-D-asparagine;MFCD00153299;Boc-Asn-(Trt)-OH;N2-Boc-N4-trityl-L-asparagine;SCHEMBL15311114;DTXSID90464258;PYGOCFDOBSXROC-QHCPKHFHSA-N;AMY40434;AKOS015892779;AKOS015924188;Nalpha-Boc-Ngamma-trityl-D-asparagine;CS-W002449;DS-1087;HY-W002449;N-Alpha-t-Boc-N-beta-trityl-asparagine;PD196399;Boc-Asn(Trt)-OH, >=99.0% (TLC);B3789;A806429;J-300047;Q-101666;N-alpha-tert-Butoxycarbonyl-N-gamma-trityl-L-asparagine;(S)-2-(tert-butoxycarbonylamino)-4-oxo-4-(tritylamino)butanoic acid;(2S)-2-{[(tert-butoxy)carbonyl]amino}-3-[(triphenylmethyl)carbamoyl]propanoic acid;(2S)-2-(tert-butoxycarbonylamino)-4-oxo-4-(tritylamino)butanoic acid;N-Alpha-t-Boc-N-gamma-trityl-asparagine

Chemical Property of Boc-Asn(Trt)-OH

Chemical Property:

• Vapor Pressure: 3.22E-21mmHg at 25°C
• Melting Point: ~205 °C (dec.)
• Refractive Index: 1.582
• Boiling Point: 711 °C at 760 mmHg
• Flash Point: 383.8 °C
• PSA: 104.73000
• Density: 1.202 g/cm³
• LogP: 5.24450
• Storage Temp.: Store at 0°C
• XLogP3: 4.5
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 10
• Exact Mass: 474.21547206
• Heavy Atom Count: 35
• Complexity: 668

Purity/Quality:

99% ^*data from raw suppliers

N-α-t-Boc-N-γ-trityl-asparagine ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)NC(CC(=O)NC(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)C(=O)O
• Isomeric SMILES: CC(C)(C)OC(=O)N[C@@H](CC(=O)NC(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)C(=O)O
• Uses: Boc-Asn(Trt)-OH

Technology Process of Boc-Asn(Trt)-OH

There total 4 articles about Boc-Asn(Trt)-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

triphenylmethyl alcohol (76-84-6) → Nα-tert-butoxycarbonyl-Nω-triphenylmethyl-L-asparagine (132388-68-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / acetic anhydride, conc.H₂SO₄ / acetic acid / 1.25 h / 60 °C

With sulfuric acid; acetic anhydride; In acetic acid;

DOI:10.1016/S0040-4039(00)74872-6

Reference yield:

N-benzyloxycarbonyl-N'-trityl-L-asparagine (132388-57-9) → Nα-tert-butoxycarbonyl-Nω-triphenylmethyl-L-asparagine (132388-68-2)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Pd-C

With hydrogen; palladium on activated charcoal;

DOI:10.1016/S0040-4039(00)74872-6

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + (S)-2-Amino-N-trityl-succinamic acid (132388-58-0,200192-49-0) → Nα-tert-butoxycarbonyl-Nω-triphenylmethyl-L-asparagine (132388-68-2)

Guidance literature:

DOI:10.1016/S0040-4039(00)74872-6

upstream raw materials:

di-tert-butyl dicarbonate

(S)-2-Amino-N-trityl-succinamic acid

triphenylmethyl alcohol

N-benzyloxycarbonyl-N'-trityl-L-asparagine

Refernces

• 1、 Sieber,Riniker. "Protection of carboxamide functions by the trityl residue. Application to peptide synthesis". . p. 739 - 742. Retrieved 2007/10/02.