Technology Process of 2-(4-(2-(allyloxy)ethoxy)benzyl)-4-bromo-1-chlorobenzene
There total 5 articles about 2-(4-(2-(allyloxy)ethoxy)benzyl)-4-bromo-1-chlorobenzene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-(4-(5-bromo-2-chlorobenzyl)phenoxy)ethanol;
With
sodium hydride;
In
tetrahydrofuran;
at 0 ℃;
for 0.5h;
allyl bromide;
In
tetrahydrofuran;
at 0 - 20 ℃;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: triethylsilane; trifluorormethanesulfonic acid; trifluoroacetic acid / 20 °C / Reflux
2.1: boron tribromide / dichloromethane / -78 - 20 °C
3.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C
3.2: 80 °C
4.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C
4.2: 0 - 20 °C
With
triethylsilane; trifluorormethanesulfonic acid; boron tribromide; sodium hydride; caesium carbonate; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 20 °C
2.1: aluminum (III) chloride / dichloromethane / -5 - 4 °C
3.1: triethylsilane; trifluorormethanesulfonic acid; trifluoroacetic acid / 20 °C / Reflux
4.1: boron tribromide / dichloromethane / -78 - 20 °C
5.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C
5.2: 80 °C
6.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C
6.2: 0 - 20 °C
With
triethylsilane; aluminum (III) chloride; oxalyl dichloride; trifluorormethanesulfonic acid; boron tribromide; sodium hydride; caesium carbonate; trifluoroacetic acid;
N,N-dimethyl-formamide;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;