1,2-Benzisoxazole-3-methanesulfonic acid sodium salt

Base Information

• Chemical Name: 1,2-Benzisoxazole-3-methanesulfonic acid sodium salt
• CAS No.: 73101-64-1
• Molecular Formula: C8H6NNaO4S
• Molecular Weight: 235.196
• Hs Code.: 2934990002
• Mol file: 73101-64-1.mol

Synonyms:1,2-Benzisoxazole-3-methanesulfonicacid, sodium salt (9CI);Sodium 1,2-benzisoxazole-3-methanesulfonate;

Chemical Property of 1,2-Benzisoxazole-3-methanesulfonic acid sodium salt

Chemical Property:

• Melting Point: 275ºC dec.
• PSA: 91.61000
• LogP: 1.95380
• Storage Temp.: -20?C Freezer

Purity/Quality:

99% ^*data from raw suppliers

1,2-Benzisoxazole-3-methanesulfonateSodiumSalt ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Zonisamide intermediate

Technology Process of 1,2-Benzisoxazole-3-methanesulfonic acid sodium salt

There total 8 articles about 1,2-Benzisoxazole-3-methanesulfonic acid sodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.26%

4-oximino-3,4-dihydro-1,2-benzoxathiin-4-one-2,2-dioxide (597563-86-5) → 1,2-benzisoxazole-3-methanesulfonic acid sodium salt (73101-64-1)

Guidance literature:

With sodium hydroxide; In monoethyleneglycol; at 25 - 90 ℃; for 3h; Product distribution / selectivity; Heating;

Reference yield: 91.9%

→ 1,2-benzisoxazole-3-methanesulfonic acid sodium salt (73101-64-1)

Guidance literature:

In ethanol; water; Purification / work up; Heating / reflux;

Reference yield: 10.0%

2-[(E)-Hydroxyimino]-2-(2-hydroxy-phenyl)-ethanesulfonic acid amide (74538-98-0) → 1,2-benzisoxazole-3-methanesulfonic acid sodium salt (73101-64-1) + 2-(o-hydroxyphenyl)-2-hydroxyiminoethanesulfonic acid ammonium salt (81516-48-5)

Guidance literature:

With sodium carbonate; at 95 ℃; for 3h;

DOI:10.1248/cpb.30.333

upstream raw materials:

2-[(E)-Hydroxyimino]-2-(2-hydroxy-phenyl)-ethanesulfonic acid amide

1,2-benzisoxazole-3-methanesulfonamide

2-Sulfamoylacetylphenol

4-oximino-3,4-dihydro-1,2-benzoxathiin-4-one-2,2-dioxide

Downstream raw materials:

1,2-benzoxazol-3-ylmethanesulfonyl chloride

1,2-benzisoxazole-3-methanesulfonamide

Refernces

• 1、 -. "PURE 1,2-BENZISOXAZOLE-3-METHANE-SULFONIC ACID SODIUM SALT AND PURIFICATION PROCESS". Page/Page column 12. . Retrieved 2008/06/13.
• 2、 -. "IMPROVED PROCESS FOR THE PREPARATION OF INTERMEDIATES USEFUL FOR THE PREPARATION OF ZONISAMIDE". Page/Page column 16-17. . Retrieved 2008/06/13.