4'-Ethylpropiophenone

Base Information

• Chemical Name: 4'-Ethylpropiophenone
• CAS No.: 27465-51-6
• Molecular Formula: C11H14O
• Molecular Weight: 162.232
• Hs Code.: 29143990
• Mol file: 27465-51-6.mol

Synonyms:Propiophenone,4'-ethyl- (6CI,8CI);1-(4-Ethylphenyl)propanone;4-Ethylpropiophenone;4'-Ethylpropiophenone;p-Ethylpropiophenone;1-(4-ethylphenyl)propan-1-one;4-Ethylpropiophenone;1-propanone, 1-(4-ethylphenyl)-;

Chemical Property of 4'-Ethylpropiophenone

Chemical Property:

• Vapor Pressure: 0.0368mmHg at 25°C
• Refractive Index: 1.504
• Boiling Point: 257.5 °C at 760 mmHg
• Flash Point: 103.2 °C
• PSA: 17.07000
• Density: 0.952 g/cm³
• LogP: 2.84170
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98% purity ^*data from raw suppliers

4-EthylPropiophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: An impurity of Eperisone (E565800) as muscle relaxant and analgesic.

Technology Process of 4'-Ethylpropiophenone

There total 11 articles about 4'-Ethylpropiophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

triethyl borane (97-94-9) + N-methyl-N-tosyl-p-chlorobenzamide (1445317-56-5) → 1-(4-ethylphenyl)-1-propanone (27465-51-6)

Guidance literature:

With [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride; potassium carbonate; In tetrahydrofuran; tert-butyl methyl ether; at 20 ℃; for 24h; Inert atmosphere; Schlenk technique;

DOI:10.3390/molecules23092412

Reference yield: 88.0%

methanol (67-56-1) + 1-(4-ethylphenyl)ethanol (33967-18-9) → 1-(4-ethylphenyl)-1-propanone (27465-51-6)

Guidance literature:

With chlorine[2-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxypyridine](pentamethylcyclopentadienyl)iridium(III) chloride; potassium hydroxide; In water; at 80 ℃; Schlenk technique; Inert atmosphere;

Reference yield: 80.0%

1-(4-ethylphenyl)prop-2-en-1-ol → 1-(4-ethylphenyl)-1-propanone (27465-51-6)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; Schlenk technique; Inert atmosphere;

DOI:10.1002/ejoc.201700440

upstream raw materials:

[1-(4-ethyl-phenyl)-vinyl]-methyl ether

ethylbenzene

propionyl chloride

propionic acid anhydride

Downstream raw materials:

α-Amino-4-ethyl-propiophenon

2-(4-ethyl-phenyl)-3-methyl-quinoline-4-carboxylic acid

3-(4-ethyl-phenyl)-propionic acid

(+/-)-1-Isopropylamino-1-(4-ethyl-benzoyl)-ethan

Refernces

• 1、 Li, Zhibin,Zhang, Yan,Li, Kuiliang,Zhou, Zhenghong,Zha, Zhenggen,Wang, Zhiyong. "Selective electrochemical oxidation of aromatic hydrocarbons and preparation of mono/multi-carbonyl compounds". . p. 2134 - 2141. Retrieved 2021/09/29.
• 2、 -. "Method for generating ketone through rearranging diazo compounds under catalysis condition of ferrous sulfate heptahydrate". Paragraph 0018; 0019; 0020; 0021; 0023; 0030; 0031; 0032. . Retrieved 2018/09/08.