(S)-(+)-4-(2,3-EPOXYPROPOXY)CARBAZOLE

Base Information

• Chemical Name: (S)-(+)-4-(2,3-EPOXYPROPOXY)CARBAZOLE
• CAS No.: 95093-95-1
• Molecular Formula: C15H13 N O2
• Molecular Weight: 239.274
• Hs Code.: 2933990090
• Mol file: 95093-95-1.mol

Synonyms:9H-Carbazole,4-(oxiranylmethoxy)-, (S)-; 9H-Carbazole, 4-[(2S)-oxiranylmethoxy]- (9CI);(2S)-3-(9H-Carbazol-4-yloxy)methyloxirane;(S)-(+)-4-(2,3-Epoxypropoxy)carbazole;(S)-(+)-4-(oxiranylmethoxy)-9H-carbazole; (S)-4-(2-Oxiranylmethoxy)carbazole;(S)-4-(Oxiranylmethoxy)-9H-carbazole; 4-(((2S)-Oxiranyl)methoxy)-9H-carbazole

Chemical Property of (S)-(+)-4-(2,3-EPOXYPROPOXY)CARBAZOLE

Chemical Property:

• Vapor Pressure: 2.23E-08mmHg at 25°C
• Melting Point: 158-160oC
• Boiling Point: 464.9°C at 760 mmHg
• Flash Point: 166.4°C
• PSA: 37.55000
• Density: 1.327g/cm³
• LogP: 3.09870
• Storage Temp.: -20°C Freezer
• Solubility.: DMSO (Slightly), Methanol (Slightly, Heated), Pyridine (Slightly)

Purity/Quality:

98%min ^*data from raw suppliers

(S)-(+)-4-(2,3-Epoxypropoxy)carbazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (S)-(+)-4-(2,3-Epoxypropoxy)carbazole (cas# 95093-95-1) is a compound useful in organic synthesis.

Technology Process of (S)-(+)-4-(2,3-EPOXYPROPOXY)CARBAZOLE

There total 7 articles about (S)-(+)-4-(2,3-EPOXYPROPOXY)CARBAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

9H-carbazol-4-ol (52602-39-8) + (2s)-(+)-glycidyl 3-nitrobenzenesulfonate (115314-14-2) → S-(+)-4-(oxiranylmethoxy)-9H-carbazole (95093-95-1,95093-96-2)

Guidance literature:

With potassium carbonate; In butanone; for 18h; Heating / reflux;

Reference yield: 91.0%

(R)-(-)-epichlorohydrin (51594-55-9,24969-06-0,13403-37-7) + 9H-carbazol-4-ol (52602-39-8) → S-(+)-4-(oxiranylmethoxy)-9H-carbazole (95093-95-1,95093-96-2)

Guidance literature:

With sodium hydroxide; In water; dimethyl sulfoxide; at 20 ℃; for 7.5h; Inert atmosphere;

DOI:10.1002/chem.201604002

Reference yield: 79.0%

→ S-(+)-4-(oxiranylmethoxy)-9H-carbazole (95093-95-1,95093-96-2)

Guidance literature:

upstream raw materials:

9H-carbazol-4-ol

(2s)-(+)-glycidyl 3-nitrobenzenesulfonate

(R)-(-)-epichlorohydrin

3-Bromophenol

Downstream raw materials:

(2 S)-1-[(4-Aminophenethyl)amino]-3-(9 H-carbazol-4-yloxy)-2-propanol

(+)-(S)-1-bromo-4-(oxiran-2-ylmethoxy)carbazole

NSC 305336

(-)-Carvedilol

Refernces

• 1、 Brütting, Christian,Hesse, Ronny,J?ger, Anne,Kataeva, Olga,Schmidt, Arndt W.,Kn?lker, Hans-Joachim. "Synthesis of Glycoborine, Glybomine A and B, the Phytoalexin Carbalexin A and the β-Adrenoreceptor Antagonists Carazolol and Carvedilol". . p. 16897 - 16911. Retrieved 2016/11/17.
• 2、 -. "BRIDGED ARYL PIPERAZINES DERIVATIVES USEFUL FOR THE TREATMENT OF CNS, GI-URINARY AND REPRODUCTIVE DISORDERS". Page/Page column 26. . Retrieved 2010/11/30.