FMOC-LYS-OH

Base Information

• Chemical Name: FMOC-LYS-OH
• CAS No.: 105047-45-8
• Molecular Formula: C21H24N2O4
• Molecular Weight: 368.433
• Hs Code.: 29225090
• European Community (EC) Number: 829-390-8
• DSSTox Substance ID: DTXSID10426671
• Nikkaji Number: J956.306G
• Wikidata: Q72478532
• Mol file: 105047-45-8.mol

Synonyms:(2S)-6-Amino-2-[[[(9H-fluoren-9-yl)methoxy]carbonyl]amino]hexanoicacid;N-a-(Fmoc)-N-e-(NH2)-L-Lysine-OH;Na-(9-Fluorenylmethoxycarbonyl)lysine;a-N-(9-Fluorenylmethyloxycarbonyl)lysine;

Chemical Property of FMOC-LYS-OH

Chemical Property:

• Vapor Pressure: 1.29E-15mmHg at 25°C
• Melting Point: 26.8 °C
• Refractive Index: 1.6
• Boiling Point: 607.6 °C at 760 mmHg
• PKA: 3.81±0.21(Predicted)
• Flash Point: 321.3 °C
• PSA: 101.65000
• Density: 1.245 g/cm³
• LogP: 4.19850
• Storage Temp.: Store at 0°C
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 9
• Exact Mass: 368.17360725
• Heavy Atom Count: 27
• Complexity: 490

Purity/Quality:

99%, ^*data from raw suppliers

Fmoc-Lys ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NC(CCCCN)C(=O)O
• Isomeric SMILES: C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)N[C@@H](CCCCN)C(=O)O
• Uses: Nα-Fmoc-L-lysine is an N-Fmoc-protected form of L-Lysine (L468895). L-Lysine is an essential amino acid for humans, with a suggested intake of 5-8 grams per day. L-Lysine can be found in a variety of food, such as eggs and quinoa, but is also mass produced by microbial fermentation. L-Lysine is also used as therapy to treat recurrent herpes simplex infections.

Technology Process of FMOC-LYS-OH

There total 20 articles about FMOC-LYS-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

Fmoc-Lys(tert-butoxycarbonyl) (71989-26-9) → Fmoc-Lys-OH (105047-45-8)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1002/ejoc.201402111 DOI:10.1002/ejoc.201403344

Reference yield: 86.3%

Fmoc-Lys(Z)-OH (86060-82-4,110990-07-3) → Fmoc-Lys-OH (105047-45-8)

Guidance literature:

With trifluorormethanesulfonic acid; 3-methyl-phenol; trifluoroacetic acid; at 4 ℃; for 1h;

DOI:10.1248/cpb.48.1230

Reference yield: 83.6%

Fmoc-Lys(ClZ)-OH (133970-31-7) → Fmoc-Lys-OH (105047-45-8)

Guidance literature:

With trifluorormethanesulfonic acid; methyl-phenyl-thioether; trifluoroacetic acid; at 4 ℃; for 1h;

DOI:10.1248/cpb.48.1230

upstream raw materials:

Fmoc-Lys(tert-butoxycarbonyl)

Fmoc-Lys(Z)-OH

Fmoc-Lys(ClZ)-OH

2-(9H-fluoren-9-ylmethoxycarbonylamino)-6-[2-(4-trifluoromethyl-benzenesulfonyl)-ethoxycarbonylamino]-hexanoic acid methyl ester

Downstream raw materials:

Fmoc-Lys(ivDde)-OH

C₂₇H₃₈N₂O₁₀P₂

(2S)-benzyl 6-formamido-2-[(4S)-2-(2-hydroxyphenyl)-Δ²-1,3-oxazoline-4-carboxamido]hexanoate

(2S)-benzyl 6-formamido-2-[(4R)-2-(2-hydroxyphenyl)-Δ²-1,3-oxazoline-4-carboxamido]hexanoate

Refernces

• 1、 Creemer, Cassidy,Kilic, Haydar,Lee, Kwang Soo,Parquette, Jon R.,Saracoglu, Nurullah. "Light-controlled self-assembly of a dithienylethene bolaamphiphile in water". supporting information. p. 8846 - 8849. Retrieved 2020/07/21.
• 2、 -. "NOVEL CXCR4 ANTAGONISTS WITH AMINO ACID SKELETON, PREPARATION THEREFOR AND BIOMEDICAL USE THEREOF". Paragraph 0081. . Retrieved 2020/09/09.