L-ALPHA-(3-THIENYL)GLYCINE

Base Information

• Chemical Name: L-ALPHA-(3-THIENYL)GLYCINE
• CAS No.: 1194-87-2
• Molecular Formula: C6H7NO2S
• Molecular Weight: 157.19
• Hs Code.: 2934999090
• Mol file: 1194-87-2.mol

Synonyms:3-Thiopheneaceticacid, a-amino-, (S)-;

Chemical Property of L-ALPHA-(3-THIENYL)GLYCINE

Chemical Property:

• Melting Point: 218-221 °C
• Boiling Point: 317.5 °C at 760 mmHg
• PKA: 1.89±0.10(Predicted)
• Flash Point: 145.8 °C
• PSA: 91.56000
• Density: 1.418 g/cm³
• LogP: 1.53280
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

L-α-(3-Thienyl)glycine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of L-ALPHA-(3-THIENYL)GLYCINE

There total 7 articles about L-ALPHA-(3-THIENYL)GLYCINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

(2R)-(-)-2-<(1S,2S)-(2-Hydroxy-1-hydroxymethyl-2-phenylethyl)amino>-2-(3-thienyl)essigsaeure (97036-30-1) → D-(-)-2-(3-Thienyl)-glycin (1194-86-1,1194-87-2,1194-88-3,38150-49-1)

Guidance literature:

With ammonium hydroxide; periodic acid; In water; Ambient temperature;

Reference yield: 50.0%

(2S)-(-)-2-<(1S,2S)-(2-Hydroxy-1-hydroxymethyl-2-phenylethyl)amino>-2-(3-thienyl)essigsaeure (97101-16-1) → L-(+)-2-(3-Thienyl)glycin (1194-86-1,1194-87-2,1194-88-3,38150-49-1)

Guidance literature:

With ammonium hydroxide; periodic acid; In water; Ambient temperature;

Reference yield:

3-thiophene carboxaldehyde (498-62-4) → L-(+)-2-(3-Thienyl)glycin (1194-86-1,1194-87-2,1194-88-3,38150-49-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 1) CH₃OH, 20 min., room temp.; 2) acetic acid, -5 degC, 2 h, -5 degC to room temp., 20 h

2: 66 percent / conc. HCl / 1) -10 degC, 1 h; 2) 0 degC, 1 h; 3) room temp., 1 h; 4) 50 degC, 4 h

3: 50 percent / periodinic acid, 2 N NH₃ / H₂O / Ambient temperature

With hydrogenchloride; ammonium hydroxide; periodic acid; In water;

upstream raw materials:

(2S)-(-)-2-<(1S,2S)-(2-Hydroxy-1-hydroxymethyl-2-phenylethyl)amino>-2-(3-thienyl)essigsaeure

3-thiophene carboxaldehyde

(4S,5S)-(+)-2,2-Dimethyl-4-phenyl-5-<(3-thienylmethylen)amino>-1,3-dioxan

(2S)-(+)-2-<(4S,5S)-(2,2-Dimethyl-4-phenyl-1,3-dioxan-5-yl)amino>-2-(3-thienyl)acetonitril

Downstream raw materials:

(S)-2-((tert-butoxycarbonyl)amino)-2-(thiophen-3-yl)acetic acid

(3S,6S)-4-(5-(4-fluorophenyl)isoxazole-3-carbonyl)-3-isobutyl-6-(thiophen-3-yl)piperazin-2-one

Refernces