(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-cyclohexylpropanoic acid

Base Information

• Chemical Name: (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-cyclohexylpropanoic acid
• CAS No.: 144701-25-7
• Molecular Formula: C₂₄H₂₇NO₄
• Molecular Weight: 393.483
• Hs Code.: 2924 29 70
• European Community (EC) Number: 879-028-8
• DSSTox Substance ID: DTXSID601148502
• Nikkaji Number: J1.878.022D
• ChEMBL ID: CHEMBL1644887
• Mol file: 144701-25-7.mol

Synonyms:Fmoc-D-Cha-OH;144701-25-7;Fmoc-beta-cyclohexyl-D-alanine;(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-cyclohexylpropanoic acid;(2R)-3-cyclohexyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid;CHEMBL1644887;Fmoc-3-cyclohexyl-D-alanine;(r)-2-(((9h-fluoren-9-yl)methoxy)carbonylamino)-3-cyclohexylpropanoic acid;n-alpha-fmoc-beta-cyclohexyl-d-alanine;SCHEMBL118173;Fmoc-(R)-3-Cyclohexylalanine;N-FMoc-3-cyclohexyl-D-alanine;N-alpha-(9-Fluorenylmethyloxycarbonyl)-D-cyclohexylalanine;DTXSID601148502;FMOC-D-3-CYCLOHEXYL ALANINE;N-|A-Fmoc-|A-cyclohexyl-D-alanine;BDBM50333186;MFCD00151912;AKOS015837428;AKOS015895834;CS-W011717;HY-W011001;(alphaR)-alpha-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]cyclohexanepropanoic acid;AC-25317;DS-15030;EN300-624001;F14556;J-300440;Q-101767;Z1982491138;N-(9H-Fluorene-9-ylmethoxycarbonyl)-3-cyclohexyl-D-alanine;(2R)-3-cyclohexyl-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid;Cyclohexanepropanoic acid, alpha-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, (alphaR)-

Chemical Property of (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-cyclohexylpropanoic acid

Chemical Property:

• Vapor Pressure: 9.3E-16mmHg at 25°C
• Refractive Index: 1.589
• Boiling Point: 610.5 °C at 760 mmHg
• PKA: 3.91±0.10(Predicted)
• Flash Point: 323 °C
• PSA: 75.63000
• Density: 1.209 g/cm³
• LogP: 5.33960
• Storage Temp.: 2-8°C
• XLogP3: 5.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 7
• Exact Mass: 393.19400834
• Heavy Atom Count: 29
• Complexity: 551

Purity/Quality:

99.3% ^*data from raw suppliers

Fmoc-beta-cyclohexyl-D-alanine ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(CC1)CC(C(=O)O)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24
• Isomeric SMILES: C1CCC(CC1)C[C@H](C(=O)O)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24
• Uses: N-Fmoc-3-cyclohexyl-D-alanine is used as fine chemical intermediate.

Technology Process of (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-cyclohexylpropanoic acid

There total 1 articles about (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-cyclohexylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(fluorenylmethoxy)carbonyl chloride (28920-43-6) + L-2-cyclohexylalanine (4441-50-3,27527-05-5,55658-63-4,58717-02-5) → N-(9-Fluorenylmethyloxy)carbonyl-L-2-cyclohexylalanine (135673-97-1,144701-25-7,144786-94-7)

Guidance literature:

With sodium carbonate; In 1,4-dioxane; water; Yield given;

DOI:10.1016/S0040-4020(01)81776-2

upstream raw materials:

(fluorenylmethoxy)carbonyl chloride

L-2-cyclohexylalanine

Refernces