FMOC-1,4-TRANS-ACHC-OH

Base Information

• Chemical Name: FMOC-1,4-TRANS-ACHC-OH
• CAS No.: 147900-46-7
• Molecular Formula: C22H23 N O4
• Molecular Weight: 365.429
• Hs Code.: 2924299090
• Mol file: 147900-46-7.mol

Synonyms:TRANS4(FMOCAMINO)CYCLOHEXANECARBOXYLICACID;FMOC1,4TRANSACHCOH;FMOCTRANS1,4AMINOCYCLOHEXANECARBOXYLICACID;FMOCTRANS4AMINOCYCLOHEXANECARBOXYLICACID;FMOCTRANS4AMINOCYCLOHEXANE1CARBOXYLICACID;Cyclohexanecarboxylicacid,4[[(9Hfluoren9ylmethoxy)carbonyl]amino],trans(9CI);TRANS1(9FLUOROENYLMETHYLOXYCARBONYLAMINO)CYCLOHEXYL4CARBOXYLICACID

Chemical Property of FMOC-1,4-TRANS-ACHC-OH

Chemical Property:

• Melting Point: 230℃ (DEC.)
• PSA: 75.63000
• Density: 1.129
• LogP: 4.55940
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

Fmoc-trans-4-aminocyclohexane carboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of FMOC-1,4-TRANS-ACHC-OH

There total 4 articles about FMOC-1,4-TRANS-ACHC-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(fluorenylmethoxy)carbonyl chloride (28920-43-6) + trans-4-aminocyclohexanecarboxylic acid hydrochloric acid (27960-59-4) → trans-4-(fluorenylmethoxycarbonylamino)cyclohexanecarboxylic acid (147900-46-7)

Guidance literature:

With potassium carbonate; In 1,4-dioxane; at 0 - 20 ℃;

DOI:10.1021/ja0457462

Reference yield:

4-amino-benzoic acid (150-13-0,159246-81-8,8014-65-1) → trans-4-(fluorenylmethoxycarbonylamino)cyclohexanecarboxylic acid (147900-46-7)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / PtO₂ / ethanol; H₂O / 2585.7 Torr / Ambient temperature

2: 1.) NaOH, 2.) NaHCO₃ / 1.) THF, H₂O, 5 min, 2.) THF, H₂O

With sodium hydroxide; hydrogen; sodium hydrogencarbonate; platinum(IV) oxide; In ethanol; water;

DOI:10.1021/jm00060a018

Reference yield:

trans-4-aminocyclohexanecarboxylic acid (1776-53-0,3685-23-2,3685-25-4,57043-03-5,66762-20-7) + N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) → trans-4-(fluorenylmethoxycarbonylamino)cyclohexanecarboxylic acid (147900-46-7)

Guidance literature:

With sodium hydroxide; sodium hydrogencarbonate; Yield given. Multistep reaction; 1.) THF, H₂O, 5 min, 2.) THF, H₂O;

DOI:10.1021/jm00060a018

upstream raw materials:

trans-4-aminocyclohexanecarboxylic acid

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

(fluorenylmethoxy)carbonyl chloride

trans-4-aminocyclohexanecarboxylic acid hydrochloric acid

Downstream raw materials:

C₅₃H₆₂N₉O₁₇PS

Refernces

• 1、 Marastoni, Mauro,Guerrini, Remo,Balboni, Gianfranco,Salvadori, Severo,Fantin, Giancarlo,Fogagnolo, Marco,Lazarus, Lawrence H.,Tomatis, Roberto. "Opioid deltorphin C analogues containing cis- or trans-2- or 3- or 4- aminocyclohexanecarboxylic acid residues". . p. 6 - 12. Retrieved 2007/10/03.