D-GLUTAMIC-2,3,3,4,4-D5 ACID

Base Information

• Chemical Name: D-GLUTAMIC-2,3,3,4,4-D5 ACID
• CAS No.: 14341-88-9
• Molecular Formula: C₅H₉NO₄
• Molecular Weight: 152.091
• Mol file: 14341-88-9.mol

Synonyms:Glutamic-2,3,3,4,4-d5acid, D- (8CI)

Chemical Property of D-GLUTAMIC-2,3,3,4,4-D5 ACID

Chemical Property:

• PSA: 100.62000
• LogP: -0.03660

Purity/Quality:

99% ^*data from raw suppliers

D-GlutamicAcid-d5 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: D-Glutamic Acid-d5 is the isotope labelled analog of D-Glutamic Acid. D-Glutamic Acid is the unnatural (R)-enantiomer of Glutamic Acid, a non-essential amino acid. Its salt form (glutamate) is an important neurotransmitter that plays a key role in long-term potentiation and is important for learning and memory. Glutamic Acid is also a key molecule in cellular metabolism.

Technology Process of D-GLUTAMIC-2,3,3,4,4-D5 ACID

There total 6 articles about D-GLUTAMIC-2,3,3,4,4-D5 ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

C5H2(2)H4O5 (1381759-60-9) → L-per-[2H5]-glutamic acid (2784-50-1,14341-88-9)

Guidance literature:

With α-D-glucopyranose-1-d₁; NAD; ammonium chloride; In water-d2; at 20 ℃; pH=7; Enzymatic reaction;

Reference yield:

→ DL-glutamic-2,3,3,4,4-D5 acid (14341-79-8,14341-88-9)

Guidance literature:

DL-Glutaminsaeure-d(5)-deuteriochlorid, Triaethylamin, W.;

Reference yield:

α-ketoglutaric acid (328-50-7) → L-per-[2H5]-glutamic acid (2784-50-1,14341-88-9)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen chloride / water-d2 / 120 h / 140 °C

2: NAD; α-D-glucopyranose-1-d₁; ammonium chloride / water-d2 / 20 °C / pH 7 / Enzymatic reaction

With α-D-glucopyranose-1-d₁; NAD; hydrogen chloride; ammonium chloride; In water-d2;

upstream raw materials:

α-ketoglutaric acid

C₅H₂⁽²⁾H₄O₅

Downstream raw materials:

C₁₄H₁₀⁽²⁾H₇NO₆

L-[δ₁-¹³CH₃;α,β,γ,δ₂-²H₇;α-¹⁵N]-leucine

L-[δ₂-¹³CH3;α,β,γ,δ₁-²H₇;α-¹⁵N]-leucine

C₅⁽¹³⁾CH₆⁽²⁾H₇⁽¹⁵⁾NO₂

Refernces