Technology Process of 5'-(dimethoxytrityl)-4,5-(1,3-[3H,6H]oxazin-2-one)deoxycytidine
There total 8 articles about 5'-(dimethoxytrityl)-4,5-(1,3-[3H,6H]oxazin-2-one)deoxycytidine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
pyridine;
at 20 ℃;
for 17h;
Inert atmosphere;
DOI:10.1021/ol102408t
- Guidance literature:
-
Multi-step reaction with 5 steps
1: sodium tetrahydroborate; cerium(III) chloride heptahydrate / methanol / 0.5 h / 20 °C / Inert atmosphere
2: tetrahydrofuran / 1.5 h / 20 °C / Inert atmosphere
3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1.5 h / Inert atmosphere
4: pyridine; pyridine hydrogenfluoride / ethyl acetate / 14 h / 20 °C / Inert atmosphere
5: pyridine / 17 h / 20 °C / Inert atmosphere
With
pyridine; sodium tetrahydroborate; cerium(III) chloride heptahydrate; pyridine hydrogenfluoride; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; methanol; ethyl acetate;
1: Luche reduction;
DOI:10.1021/ol102408t
- Guidance literature:
-
Multi-step reaction with 8 steps
1: iodine; 3-chloro-benzenecarboperoxoic acid / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere
2: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere
3: tris(dibenzylideneacetone)dipalladium(0) chloroform complex; tri-n-butyl-tin hydride; triphenylphosphine / toluene / 60 °C / 2625.26 Torr / Autoclave; Inert atmosphere
4: sodium tetrahydroborate; cerium(III) chloride heptahydrate / methanol / 0.5 h / 20 °C / Inert atmosphere
5: tetrahydrofuran / 1.5 h / 20 °C / Inert atmosphere
6: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1.5 h / Inert atmosphere
7: pyridine; pyridine hydrogenfluoride / ethyl acetate / 14 h / 20 °C / Inert atmosphere
8: pyridine / 17 h / 20 °C / Inert atmosphere
With
pyridine; 1H-imidazole; tris(dibenzylideneacetone)dipalladium(0) chloroform complex; sodium tetrahydroborate; cerium(III) chloride heptahydrate; iodine; tri-n-butyl-tin hydride; pyridine hydrogenfluoride; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine;
In
tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide; toluene;
4: Luche reduction;
DOI:10.1021/ol102408t