Boc-cis-3-hydroxy-l-proline

Base Information Edit

Chemical Name:Boc-cis-3-hydroxy-l-proline
CAS No.:186132-96-7
Molecular Formula:C10H17 N O5
Molecular Weight:231.249
Hs Code.:2933998090
European Community (EC) Number:814-501-4,846-072-4
DSSTox Substance ID:DTXSID00455091
Nikkaji Number:J791.992A
Wikidata:Q72481688
Mol file:186132-96-7.mol

Synonyms:Boc-cis-3-hydroxy-l-proline;186132-96-7;(2S,3R)-1-(tert-Butoxycarbonyl)-3-hydroxypyrrolidine-2-carboxylic acid;(2S,3R)-3-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic Acid;(2S,3R)-1-BOC-3-hydroxypyrrolidine-2-carboxylic acid;(2S,3R)-3-hydroxy-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester;186132-80-9;cis-1-(Tert-butoxycarbonyl)-3-hydroxypyrrolidine-2-carboxylic acid;MFCD08458682;SCHEMBL694280;AMY271;N-boc-cis-3-hydroxy-L-proline;DTXSID00455091;JLDHXHPQMBNKMC-RQJHMYQMSA-N;N-BOC-3-(R)-hydroxy-L-proline;AKOS015910896;FS-6312;CS-0097226;EN300-741868;N-t-BOC-cis-3-Hydroxy-L-proline, AldrichCPR;P19082;N-(tert-butoxycarbonyl)-cis-3-hydroxy-L-proline;1-(tert-Butoxycarbonyl)-3alpha-hydroxy-L-proline;Z2680628469;cis-1-(Tert-butoxycarbonyl)-3-hydroxypyrrolidine-2-carboxylicacid;(2S,3R)-1-[(tert-butoxy)carbonyl]-3-hydroxypyrrolidine-2-carboxylic acid;rac-(2R,3S)-1-[(tert-butoxy)carbonyl]-3-hydroxypyrrolidine-2-carboxylic acid

Suppliers and Price of Boc-cis-3-hydroxy-l-proline

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Boc-cis-3-hydroxy-L-proline
100mg
$ 360.00

TRC
Boc-cis-3-hydroxy-L-proline
250mg
$ 120.00

SynQuest Laboratories
N-Boc-cis-3-hydroxy-L-proline
1 g
$ 395.00

Medical Isotopes, Inc.
Boc-cis-3-hydroxy-L-proline
15 g
$ 1800.00

Chemenu
(2S,3R)-1-(tert-Butoxycarbonyl)-3-hydroxypyrrolidine-2-carboxylicacid 95%
1g
$ 496.00

Biosynth Carbosynth
Boc-cis-3-hydroxy-L-proline
100 mg
$ 200.00

Biosynth Carbosynth
Boc-cis-3-hydroxy-L-proline
50 mg
$ 130.00

Biosynth Carbosynth
Boc-cis-3-hydroxy-L-proline
25 mg
$ 85.00

Biosynth Carbosynth
Boc-cis-3-hydroxy-L-proline
500 mg
$ 600.00

Biosynth Carbosynth
Boc-cis-3-hydroxy-L-proline
250 mg
$ 400.00

Total 21 raw suppliers

Chemical Property of Boc-cis-3-hydroxy-l-proline Edit

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:390.873°C at 760 mmHg
PKA:3.69±0.40(Predicted)
Flash Point:190.193°C
PSA：87.07000
Density:1.312±0.06 g/cm3 (20 ºC 760 Torr)
LogP:0.37920
Storage Temp.:Store at RT
XLogP3:0.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:231.11067264
Heavy Atom Count:16
Complexity:296

Purity/Quality:

99% ^*data from raw suppliers

Boc-cis-3-hydroxy-L-proline ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCC(C1C(=O)O)O
Isomeric SMILES:CC(C)(C)OC(=O)N1CC[C@H]([C@H]1C(=O)O)O
Uses Boc-cis-3-hydroxy-L-proline is used to prepare analogs of cyclothialidine, a DNA-gyrase inhibitor with antibacterial activities. It is also used to synthesize potent 3- or 4-substituted-2-cyanopyrrolidine dipeptidyl peptidase IV inhibitors.

Technology Process of Boc-cis-3-hydroxy-l-proline

There total 13 articles about Boc-cis-3-hydroxy-l-proline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 567-35-1,567-36-2,4298-05-9,4298-06-0,4298-08-2,14916-76-8,62182-84-7,104069-26-3,118492-86-7,119677-21-3
(2S,3R)-3-hydroxyproline

: 186132-96-7,335280-19-8
(2S,3R)-1-[(tert-butoxy)carbonyl]-3-hydroxypyrrolidine-2-carboxylic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; water; at 0 - 20 ℃;
DOI:10.1039/b821952d

Reference yield: 90.0%

: 186132-96-7,335280-19-8
(2S,3R)-1-[(tert-butoxy)carbonyl]-3-hydroxypyrrolidine-2-carboxylic acid

Guidance literature:

Reference yield: 89.0%

: 186132-95-6
2-benzyl 1-(tert-butyl)(2S,3R)-3-hydroxypyrrolidine-1,2-dicarboxylate

: 186132-96-7,335280-19-8
(2S,3R)-1-[(tert-butoxy)carbonyl]-3-hydroxypyrrolidine-2-carboxylic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; for 0.5h; Ambient temperature;
DOI:10.1002/hlca.19960790816