4-FLUOROPHENYLZINC BROMIDE

Base Information

• Chemical Name: 4-FLUOROPHENYLZINC BROMIDE
• CAS No.: 181705-93-1
• Molecular Formula: C6H4BrFZn
• Molecular Weight: 240.39
• Hs Code.: 29319090
• Mol file: 181705-93-1.mol

Synonyms:4-Fluorophenylzincbromide;Bromo(4-fluorophenyl)zinc;

Chemical Property of 4-FLUOROPHENYLZINC BROMIDE

Chemical Property:

• Vapor Pressure: 79.9mmHg at 25°C
• Boiling Point: 84.7°C at 760 mmHg
• Flash Point: 1 °F
• PSA: 0.00000
• Density: 0.992 g/mL at 25 °C
• LogP: 2.47150
• Storage Temp.: 2-8°C
• Sensitive.: Air Sensitive

Purity/Quality:

98%min ^*data from raw suppliers

4-Fluorophenylzinc bromide solution 0.5M in THF ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F,Xn
• Hazard Codes: F,Xn
• Statements: 19-22-36/38-40-36/37-14-11
• Safety Statements: 16-26-33-36-36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-FLUOROPHENYLZINC BROMIDE

There total 7 articles about 4-FLUOROPHENYLZINC BROMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

1-Bromo-4-fluorobenzene (460-00-4) + zinc (7440-66-6) → fluorobenzene (462-06-6) + 4,4'-difluorobiphenyl (398-23-2) + 4-fluorophenylzinc bromide (181705-93-1)

Guidance literature:

With trifluoroacetic acid; cobalt(II) bromide; zinc dibromide; In acetonitrile; the mixt. in CH3CN was stirred at room temp., then arylbromide was added, stirred at room temp.; GC analysis;

DOI:10.1021/ja0289494

Reference yield:

1-Bromo-4-fluorobenzene (460-00-4) + zinc(II) chloride (7646-85-7,24359-56-6) → 4-fluorophenylzinc bromide (181705-93-1)

Guidance literature:

1-Bromo-4-fluorobenzene; With iodine; magnesium; In tetrahydrofuran; at 48 ℃;

zinc(II) chloride; In tetrahydrofuran; at 0 ℃;

Reference yield:

4-flourophenylmagnesium bromide (352-13-6) + zinc(II) chloride (7646-85-7,24359-56-6) → 4-fluorophenylzinc bromide (181705-93-1)

Guidance literature:

In toluene; at 0 - 5 ℃; for 1h;

upstream raw materials:

4-flourophenylmagnesium bromide

zinc(II) chloride

1-Bromo-4-fluorobenzene

zinc

Downstream raw materials:

(Z)-1,4-bis[(4-methoxyphenyl)methoxy]-2-(4-fluorophenyl)-but-2-ene

(4-fluorophenyl)piperidine

N-(4-fluorophenyl)tetrahydropyrrole

N,N-diethyl-4-methoxyaniline

Refernces

• 1、 Herath, Ananda,Molteni, Valentina,Pan, Shifeng,Loren, Jon. "Generation and Cross-Coupling of Organozinc Reagents in Flow". supporting information. p. 7429 - 7432. Retrieved 2019/01/03.
• 2、 Wagschal, Simon,Guilbaud, Johan,Rabet, Pauline,Farina, Vittorio,Lemaire, Sébastien. "α-C-Glycosides via syn Opening of 1,2-Anhydro Sugars with Organozinc Compounds in Toluene/n-Dibutyl Ether". . p. 9328 - 9335. Retrieved 2015/09/28.