4-(((tert-Butoxycarbonyl)amino)methyl)cyclohexanecarboxylic acid

Base Information

• Chemical Name: 4-(((tert-Butoxycarbonyl)amino)methyl)cyclohexanecarboxylic acid
• CAS No.: 162046-58-4
• Molecular Formula: C13H23NO4
• Molecular Weight: 257.33
• Hs Code.: 2924299090
• European Community (EC) Number: 830-276-5
• DSSTox Substance ID: DTXSID601347564
• Nikkaji Number: J3.151.644G,J3.151.645E
• Mol file: 162046-58-4.mol

Synonyms:162046-58-4;27687-14-5;BOC-TRANEXAMIC ACID;4-(((tert-Butoxycarbonyl)amino)methyl)cyclohexanecarboxylic acid;Boc-4-Amc-OH;847416-70-0;trans-4-(tert-Butoxycarbonylaminomethyl)cyclohexanecarboxylic Acid;4-[[(2-methylpropan-2-yl)oxycarbonylamino]methyl]cyclohexane-1-carboxylic Acid;trans-4-N-Boc-Aminomethyl-cyclohexanecarboxylic acid;trans-4-(((tert-Butoxycarbonyl)amino)methyl)cyclohexanecarboxylic acid;4-(tert-Butoxycarbonylaminomethyl)cyclohexanecarboxylic Acid;MFCD00673773;4-({[(tert-butoxy)carbonyl]amino}methyl)cyclohexane-1-carboxylic acid;Boc-trans-4-(aminomethyl)-cyclohexane-1-carboxylic acid;cis-(1,1-Dimethylethoxy)carbonyl Tranexamic Acid;cis-4-(((tert-Butoxycarbonyl)amino)methyl)cyclohexanecarboxylic acid;Cis-(4-BOC-Aminomethyl)-cyclohexyl carboxylic acid;4-(([(TERT-BUTOXY)CARBONYL]AMINO)METHYL)CYCLOHEXANE-1-CARBOXYLIC ACID;MFCD01862289;trans-4-[(Boc-amino)methyl]cyclohexanecarboxylic Acid;trans-4-{[(tert-butoxycarbonyl)amino]methyl}cyclohexanecarboxylic acid;4-[(Boc-amino)methyl]cyclohexanecarboxylic Acid;Boc-trans-4-(aminomethyl)cyclohexanecarboxylic acid;cis,trans-(1,1-Dimethylethoxy)carbonylTranexamicAcid-13C2,15N;4-(([(tert-Butoxy)carbonyl]amino)methyl)-cyclohexane-1-carboxylic acid;(1r,4r)-4-({[(tert-butoxy)carbonyl]amino}methyl)cyclohexane-1-carboxylic acid;4-((BOC-amino)methyl)cyclohexanecarboxylic acid;trans-Boc-tranexamic acid;4-[[(tert-butoxycarbonyl)amino]methyl]cyclohexanecarboxylic acid;cis-4-{[(tert-butoxycarbonyl)amino]methyl}cyclohexanecarboxylic acid;4-(Boc-aminomethyl)cyclohexanecarboxylic Acid;cyclohexanecarboxylic acid, 4-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-, trans-;Oprea1_175352;Oprea1_341039;trans-4-(Boc-aminomethyl)cyclohexanecarboxylic Acid;SCHEMBL353639;SCHEMBL353652;SCHEMBL5006161;SCHEMBL9885051;SCHEMBL9885629;AZEKNJGFCSHZID-AOOOYVTPSA-N;AZEKNJGFCSHZID-MGCOHNPYSA-N;AZEKNJGFCSHZID-UHFFFAOYSA-N;DTXSID601347564;CBA68714;CS-M2057;BBL028866;STK716513;trans-4-(tert-Butoxycarbonylamino-methyl)-cyclohexanecarboxylic acid;(1r,4r)-4-(((tert-butoxycarbonyl)amino)methyl)cyclohexanecarboxylic acid;AKOS001064296;AKOS005175122;AKOS032957128;AB86500;BS-4733;AC-29648;AS-37069;SY042490;SY056643;B3251;B3253;CS-0127783;CS-0127908;FT-0667444;FT-0679721;FT-0752291;EN300-99589;D85968;EN300-157668;F31156;A848421;A883020;A934958;A1-50247;N-Boc-trans-4-(aminomethyl)cyclohexanecarboxylic acid;Z56887262;4-((tert-butoxycarbonylamino)methyl)cyclohexanecarboxylic acid;4-(tert-Butoxycarbonylamino-methyl)-cyclohexanecarboxylic acid;trans-4-(t-butoxycarbonyl)aminomethylcyclohexylcarboxylic acid;Trans-4-(t-butoxycarbonylamino-methyl)cyclohexanecarboxylic acid;Trans-4-(t-butoxycarbonylaminomethyl)cyclohexanecarboxylic acid;trans-4-(t-butoxycarbonylaminomethyl)cyclohexyl carboxylic acid;trans-4-(t-butoxycarbonylaminomethyl)cyclohexylcarboxylic acid;trans-4-(t-butyloxycarbonyl)aminomethylcyclohexylcarboxylic acid;trans-4-[(tert-Butoxyformamido)methyl]cyclohexanecarboxylic acid;4-(((tert-Butoxycarbonyl)amino)methyl)cyclohexane-1-carboxylic acid;4-[[(tert-butoxycarbonyl)-amino]methyl] cyclohexanecarboxylic acid;4-[[(tert-butoxycarbonyl)-amino]methyl]-cyclohexanecarboxylic acid;4-[[(tert-butoxycarbonyl)-amino]methyl]cyclohexanecarboxylic acid;4-[[(tert-butoxycarbonyl)amino]methyl] cyclohexanecarboxylic acid;trans-4 (tert-Butoxycarbonylamino-methyl)-cyclohexanecarboxylic acid;trans-4- (tert-Butoxycarbonylamino-methyl)-cyclohexanecarboxylic acid;TRANS-4-(T-BUTYLOXYCARBONYLAMINOMETHYL)-CYCLOHEXANOIC ACID;Trans-4-(t-butyloxycarbonylaminomethyl)cyclohexanecarboxylic acid;trans-4-(tert-butoxycarbonylamino-methyl)-cyclo-hexanecarboxylic acid;trans-4-(tert-butoxycarbonylamino-methyl)-cyclohexane-carboxylic acid;trans-4-(tert-butoxycarbonylamino-methyl)cyclohexanecarboxylic acid;trans-4-(tert.-butoxycarbonylaminomethyl) cyclohexanecarboxylic acid;trans-4-(tert.-butyloxycarbonylaminomethyl)cyclohexanecarboxylic acid;trans-4-{[(t-butoxycarbonyl) amino]methyl}cyclohexanecarboxylic acid;Trans-4-tert-butyloxycarbonylaminomethylcyclohexane carboxylic acid;trans-4-tert-Butyloxycarbonylaminomethylcyclohexanecarboxylic Acid;trans-N-(t-butoxycarbonyl)-4-(aminomethyl)cyclohexylcarboxylic acid;cis-4-(((tert-Butoxycarbonyl)amino)methyl)cyclohexane-1-carboxylic acid;cis-4-{[(tert-butoxycarbonyl)amino]methyl}-cyclohexanecarboxylic acid;N-(tert-butoxycarbonyl)-trans-4-(aminomethyl )-1-cyclohexanecarboxylic acid;trans-4-(tert.-butyloxycarbonylaminomethyl) cyclohexanecarboxylic acid;trans-4-{[(tert-butoxy)carbonylamino]methyl}cyclohexane carboxylic acid;trans-4-{[(tert-butoxy)carbonylamino]methyl}cyclohexanecarboxylic acid;trans-4-{[(tert-butoxycarbonyl)-amino]methyl}cyclohexanecarboxylic acid;(1s,4s)-4-({[(tert-butoxy)carbonyl]amino}methyl)cyclohexane-1-carboxylic acid;cis-4-[({[(2-methyl-2-propanyl)oxy]carbonyl}amino)methyl]cyclohexanecarboxylic acid;Cyclohexanecarboxylic acid, 4-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-;trans-4-[({[(2-methyl-2-propanyl)oxy]carbonyl}amino)methyl]cyclohexanecarboxylic acid;(1r,4r)-4-(((tert-butoxycarbonyl)amino)methyl)cyclohexane-1-carboxylic acid;Boc-(4-aminomethyl)cyclohexane carboxylic acid;trans-4-(tert-Butoxycarbonylaminomethyl)cyclohexanecarboxylic acid;TRANS-4-N-BOC-AMINOMETHYL-CYCLOHEXANECARBOXYLIC ACID

Chemical Property of 4-(((tert-Butoxycarbonyl)amino)methyl)cyclohexanecarboxylic acid

Chemical Property:

• Vapor Pressure: 7.17E-08mmHg at 25°C
• Refractive Index: 1.482
• Boiling Point: 410 °C at 760 mmHg
• Flash Point: 201.8 °C
• PSA: 75.63000
• Density: 1.096 g/cm³
• LogP: 2.79300
• Storage Temp.: Store at 0°C
• Solubility.: Chloroform, Ethyl Acetate
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 257.16270821
• Heavy Atom Count: 18
• Complexity: 301

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-[[(t-Butoxycarbonyl)amino]methyl]cyclohexanecarboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)NCC1CCC(CC1)C(=O)O
• Uses: 4-[[(t-Butoxycarbonyl)amino]methyl]cyclohexanecarboxylic Acid is an intermediate in synthesizing cis-Tranexamic Acid (T714500), which is antifibrinolytic agent; blocks lysine binding sites of plasminogen. Hemostatic.

Technology Process of 4-(((tert-Butoxycarbonyl)amino)methyl)cyclohexanecarboxylic acid

There total 5 articles about 4-(((tert-Butoxycarbonyl)amino)methyl)cyclohexanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

di-tert-butyl dicarbonate (24424-99-5) + 4-aminomethyl-cyclohexanecarboxylic acid (1197-17-7,1197-18-8,701-54-2) → 4-(N-tert-butyloxycarbonylaminomethyl)-cyclohexane-1-carboxylic acid (162046-58-4)

Guidance literature:

With potassium hydrogencarbonate; In 1,4-dioxane; for 18h;

Reference yield: 64.0%

tranexamic acid + di-tert-butyl dicarbonate (24424-99-5) → 4-(N-tert-butyloxycarbonylaminomethyl)-cyclohexane-1-carboxylic acid (162046-58-4)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; water; at 20 ℃; for 5h;

Reference yield:

C24H36N2O5 → 4-(N-tert-butyloxycarbonylaminomethyl)-cyclohexane-1-carboxylic acid (162046-58-4)

Guidance literature:

C₂₄H₃₆N₂O₅; With sodium hydroxide; water; In methanol; at 20 ℃; for 3h;

With hydrogenchloride; In water; pH=1;

upstream raw materials:

di-tert-butyl dicarbonate

trans-4-aminomethyl-cyclohexyl-carboxylic acid

4-aminomethyl-cyclohexanecarboxylic acid

1,4-dioxane

Downstream raw materials:

[4-(6-chloro-3-methyl-4,10-dihydro-3H-2,3,4,9-tetraaza-benzo[f]azulene-9-carbonyl)-cyclohexylmethyl]-carbamic acid tert-butyl ester

phthalidyl trans-4-aminomethylcyclohexanecarboxylate hydrochloride

1-(isopropyloxycarbonyloxy)ethyl trans-4-aminomethylcyclohexanecarboxylate hydrochloride

Refernces

• 1、 -. "Heterocyclic Compounds". . . Retrieved 2009/10/30.
• 2、 -. "ENZYME INHIBITORS". Page/Page column 159; 160. . Retrieved 2008/06/13.