Codeine 6-Methanesulfonate

Base Information

• Chemical Name: Codeine 6-Methanesulfonate
• CAS No.: 22952-80-3
• Molecular Formula: C₁₉H₂₃NO₅S
• Molecular Weight: 377.461
• Mol file: 22952-80-3.mol

Synonyms:C₁₉H₂₃NO₅S

Chemical Property of Codeine 6-Methanesulfonate

Chemical Property:

• Melting Point: 133 °C
• Boiling Point: 556.0±50.0 °C(Predicted)
• PKA: 7.75±0.40(Predicted)
• Density: 1.41±0.1 g/cm3(Predicted)

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Protected Codeine (C634075). Present in opium from 0.7% to 2.5%, depending on the source. Weak narcotic analgesic, perhaps due to conversion to morphine, with minimal hypnotic properties; potent antit ussive.

Technology Process of Codeine 6-Methanesulfonate

There total 4 articles about Codeine 6-Methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methanesulfonyl chloride (124-63-0) + codeine (76-57-3) → C19H23NO5S (22952-80-3)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 1h;

DOI:10.1007/s00706-011-0635-y

Reference yield:

→ 6-O-Mesyl-codein (22952-80-3)

Guidance literature:

Codein, Mesylchlorid;

Reference yield:

→ 6-o-Mesylcodein (22952-80-3)

Guidance literature:

14-Hydroxymorphin-derivat;

upstream raw materials:

methanesulfonyl chloride

codeine

Downstream raw materials:

desomorphine

desocodiene

Refernces

• 1、 Makleit,Berenyi,Bognar,Elek. "Conversions of tosyl and mesyl derivatives of the morphine group, XX. Synthesis of mesyl esters". . p. 161 - 163. Retrieved 2007/10/10.