2,4-Dichloro-5-nitropyridine

Base Information

• Chemical Name: 2,4-Dichloro-5-nitropyridine
• CAS No.: 4487-56-3
• Molecular Formula: C5H2Cl2N2O2
• Molecular Weight: 192.989
• Hs Code.: 2933399090
• European Community (EC) Number: 640-198-1
• DSSTox Substance ID: DTXSID70483644
• Wikidata: Q72467145
• Mol file: 4487-56-3.mol

Synonyms:2,4-dichloro-5-nitropyridine;4487-56-3;2,4-dichloro-5-nitro-pyridine;MFCD07368834;SCHEMBL57316;2.4-dichloro-5-nitropyridine;DTXSID70483644;RZVJQUMDJUUBBF-UHFFFAOYSA-N;Pyridine, 2,4-dichloro-5-nitro-;BCP07138;CS-D1604;2,4-bis(chloranyl)-5-nitro-pyridine;AKOS005145610;2 pound not4-Dichloro-5-nitropyridine;AC-2409;PB12455;PS-3888;HY-34054;SY005528;2,4-Dichloro-5-nitropyridine, AldrichCPR;A7108;AM20080611;D4752;FT-0650374;EN300-104439;A826688;J-507139

Chemical Property of 2,4-Dichloro-5-nitropyridine

Chemical Property:

• Appearance/Colour: Light yellow needles
• Vapor Pressure: 0.006mmHg at 25°C
• Melting Point: 42.0 to 46.0 °C
• Refractive Index: 1.603
• Boiling Point: 282.329 °C at 760 mmHg
• PKA: -2.49±0.10(Predicted)
• Flash Point: 124.548 °C
• PSA: 58.71000
• Density: 1.63 g/cm³
• LogP: 2.81980
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility.: soluble in Methanol
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 191.9493327
• Heavy Atom Count: 11
• Complexity: 161

Purity/Quality:

99% ^*data from raw suppliers

2,4-Dichloro-5-nitropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,T
• Statements: 25
• Safety Statements: 45

MSDS Files:

Useful:

• Canonical SMILES: C1=C(C(=CN=C1Cl)[N+](=O)[O-])Cl
• Uses: 2,4-Dichloro-5-nitropyridine is used in the synthesis of potent and selective stearoyl-CoA desaturase (SCD) inhibitors. Also used in preparation of Rho-Kinase inhibitors displaying antihypertensive ac tivity. 2,4-Dichloro-5-nitropyridine is used in the synthesis of potent and selective stearoyl-CoA desaturase (SCD) inhibitors. Also used in preparation of Rho-Kinase inhibitors displaying antihypertensive activity.

Technology Process of 2,4-Dichloro-5-nitropyridine

There total 8 articles about 2,4-Dichloro-5-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

4,6-dichloropyridin-3-ylamine (7321-93-9) → 2,4-dichloro-5-nitropyridine (4487-56-3)

Guidance literature:

With sulfuric acid; dihydrogen peroxide; In water; at 0 - 25 ℃; for 18h;

Reference yield: 74.0%

4-chloro-2-hydroxy-5-nitropyridine (850663-54-6) → 2,4-dichloro-5-nitropyridine (4487-56-3)

Guidance literature:

With trichlorophosphate; In toluene; for 6h; Heating;

DOI:10.1021/jm060873p

Reference yield: 66.0%

4-(ethyloxy)-5-nitro-2-pyridinol → 2,4-dichloro-5-nitropyridine (4487-56-3)

Guidance literature:

With trichlorophosphate; at 100 ℃; for 12h;

upstream raw materials:

4-chloro-2-hydroxy-5-nitropyridine

4-hydroxy-3-nitropyridine

4-chloro-3-nitropyridine

2-amino-4-chloro-5-nitropyridine

Downstream raw materials:

GSK₂₆₉₉₆₂A

N-(3-{[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy}phenyl)-4-methylbenzenesulfonamide

2-cyano-N-{4-(ethylamino)-6-[(3-{[(4-methylphenyl)sulfonyl]amino}phenyl)oxy]-3-pyridinyl}acetamide

N-(3-{[2-(cyanomethyl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy}phenyl)-4-methylbenzenesulfonamide

Refernces

• 1、 Hennessy, Edward J.,Oza, Vibha,Adam, Ammar,Byth, Kate,Castriotta, Lillian,Grewal, Gurmit,Hamilton, Geraldine A.,Kamhi, Victor M.,Lewis, Paula,Li, Danyang,Lyne, Paul,?ster, Linda,Rooney, Michael T.,Saeh, Jamal C.,Sha, Li,Su, Qibin,Wen, Shengua,Xue, Yafeng,Yang, Bin. "Identification and Optimization of Benzimidazole Sulfonamides as Orally Bioavailable Sphingosine 1-Phosphate Receptor 1 Antagonists with in Vivo Activity". . p. 7057 - 7075. Retrieved 2015/09/22.
• 2、 -. "Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators". Paragraph 0126; 0128. . Retrieved 2015/01/18.