H-GLU(OBZL)-OTBU HCL

Base Information

• Chemical Name: H-GLU(OBZL)-OTBU HCL
• CAS No.: 105590-97-4
• Molecular Formula: C16H23NO4.ClH
• Molecular Weight: 329.824
• Hs Code.: 2922499990
• Mol file: 105590-97-4.mol

Synonyms:L-Glutamicacid, 1-(1,1-dimethylethyl) 5-(phenylmethyl) ester, hydrochloride (9CI);

Chemical Property of H-GLU(OBZL)-OTBU HCL

Chemical Property:

• PSA: 78.62000
• LogP: 3.68130
• Storage Temp.: 2-8°C
• Solubility.: DMSO, Methanol

Purity/Quality:

98%,99%, ^*data from raw suppliers

H-Glu(obzl)-otbuHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

• Uses: L-Glutamic Acid 1-(1,1-Dimethylethyl) 5-(Phenylmethyl) Ester Hydrochloride, is a versatile building block in the peptide chemistry. It can be used in the synthesis of series of dynamic peptides. H-Glu(obzl)-otbu HCl

Technology Process of H-GLU(OBZL)-OTBU HCL

There total 2 articles about H-GLU(OBZL)-OTBU HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

acetic acid tert-butyl ester (540-88-5) + L-glutamic acid γ-benzyl ester (1676-73-9,25014-27-1) → L-glutamic acid γ-benzyl α-tert-butyl ester hydrochloride (105590-97-4)

Guidance literature:

acetic acid tert-butyl ester; L-glutamic acid γ-benzyl ester; With perchloric acid; sodium carbonate; at 25 ℃; pH=7 - 8; Cooling with ice;

With hydrogenchloride; In diethyl ether; water; pH=4-5;

Reference yield:

L-glutamic acid γ-benzyl ester (1676-73-9,25014-27-1) + isobutene (115-11-7,15220-85-6) → L-glutamic acid γ-benzyl α-tert-butyl ester hydrochloride (105590-97-4)

Guidance literature:

With hydrogenchloride; sulfuric acid; Yield given; 1.) dioxane, 20 deg C, 4 d; 2.) ether, -10 deg C;

Reference yield: 100.0%

4-methyl-benzoyl chloride (874-60-2) + L-glutamic acid γ-benzyl α-tert-butyl ester hydrochloride (105590-97-4) → 5-benzyl 1-tert-butyl N-(4-methylbenzoyl)-L-glutamate (223467-27-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In chloroform; at 20 ℃; for 1h;

DOI:10.1016/j.bmc.2005.04.051

upstream raw materials:

L-glutamic acid γ-benzyl ester

isobutene

acetic acid tert-butyl ester

Downstream raw materials:

γ-benzyl α-tert-butyl N-phenylmethoxycarbonyl-L-prolyl-L-valyl-2-methylalanyl-2-methylalanyl-L-glutamate

(S)-2-{(S)-4-Benzyloxycarbonyl-2-[2-(2-{(S)-2-[((S)-1-benzyloxycarbonyl-pyrrolidine-2-carbonyl)-amino]-3-methyl-butyrylamino}-2-methyl-propionylamino)-2-methyl-propionylamino]-butyrylamino}-pentanedioic acid 5-benzyl ester 1-tert-butyl ester

Fmoc-Tyr-Glu(OBzl)-OtBu

5-benzyl 1-tert-butyl N-(4-methylbenzoyl)-L-glutamate

Refernces

• 1、 Shaw, I. M.,Taylor, A.. "THE CHEMISTRY OF PEPTIDES RELATED TO METABOLITES OF TRICHODERMA SPP. 2. AN IMPROVED METHOD OF CHARACTERIZATION OF PEPTIDES OF 2-METHYLALANINE". . p. 164 - 173. Retrieved 2007/10/02.