H-ACPC-OET HCL

Base Information

• Chemical Name: H-ACPC-OET HCL
• CAS No.: 42303-42-4
• Molecular Formula: C6H11NO2^.HCl
• Molecular Weight: 165.62
• Hs Code.: 29224999
• Mol file: 42303-42-4.mol

Synonyms:Cyclopropanecarboxylicacid, 1-amino-, ethyl ester, hydrochloride (9CI);1-(Ethoxycarbonyl)cyclopropanaminiumchloride;1-Aminocyclopropanecarboxylic acid ethyl ester hydrochloride;Ethyl1-aminocyclopropane-1-carboxylate hydrochloride;NSC 677920;

Chemical Property of H-ACPC-OET HCL

Chemical Property:

• Vapor Pressure: 2.47mmHg at 25°C
• Melting Point: gt. 110.0 and le 118.0 °C
• Boiling Point: 159.7 °C at 760 mmHg
• Flash Point: 33.9 °C
• PSA: 52.32000
• LogP: 1.15300
• Storage Temp.: Store at 0°C
• Water Solubility.: Soluble in water

Purity/Quality:

99% ^*data from raw suppliers

Ethyl 1-Aminocyclopropanecarboxylate Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36-38-36/37-24/25-22-7/9-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of H-ACPC-OET HCL

There total 6 articles about H-ACPC-OET HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethanol (64-17-5) + aminocyclopropane-1-carboxylic acid (22059-21-8) → ethyl 1-aminocyclopropanecarboxylate hydrochloride (42303-42-4)

Guidance literature:

With thionyl chloride; at 0 ℃; for 2h; Reflux; Green chemistry;

Reference yield: 100.0%

1-tert-butoxycarbonylamino-cyclopropanecarboxylic Acid Ethyl Ester (107259-05-2) → ethyl 1-aminocyclopropanecarboxylate hydrochloride (42303-42-4)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 0 - 20 ℃; for 5h; Inert atmosphere;

DOI:10.1021/acs.joc.0c02640

Reference yield:

ethyl 1-aminocyclopropane-1-carboxylate (72784-47-5) → ethyl 1-aminocyclopropanecarboxylate hydrochloride (42303-42-4)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at -30 - 0 ℃; for 0.5h;

upstream raw materials:

ethanol

aminocyclopropane-1-carboxylic acid

1-tert-butoxycarbonylamino-cyclopropanecarboxylic Acid Ethyl Ester

ethyl 1-aminocyclopropane-1-carboxylate

Downstream raw materials:

6-(2-bromo-5-chloro-4-fluoro-phenyl)-4,6-diaza-spiro[2.4]heptane-5,7-dione

1-tert-butoxycarbonylamino-cyclopropanecarboxylic Acid Ethyl Ester

ethyl 1-(benzoylamino)cyclopropanecarboxylic acid

tert-butyl 4-(4-(1-(ethoxycarbonyl)cyclopropylamino)-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-ylamino)benzoate

Refernces

• 1、 -. "Preparation method of 4,7-diazaspiro[2.5]octane derivative". Paragraph 0073; 0074; 0075; 0076. . Retrieved 2018/12/13.
• 2、 -. "NOVEL COMPOUNDS". Page/Page column 129. . Retrieved 2014/10/03.