BOC-D-GLU(OCHEX)-OH

Base Information

• Chemical Name: BOC-D-GLU(OCHEX)-OH
• CAS No.: 133464-27-4
• Molecular Formula: C₁₆H₂₇NO₆
• Molecular Weight: 329.393
• Mol file: 133464-27-4.mol

Synonyms:N-A-T-BUTOXYCARBONYL-D-GLUTAMIC ACID GAMMA-CYCOHEXYL ESTER;BOC-D-GLU(OCHEX)-OH;BOC-D-GLU(OCHX)-OH;BOC-D-GLUTAMIC ACID GAMMA-CYCLOHEXYL ESTER;BOC-D-GLUTAMIC ACID(OCHEX)-OH;BOC-D-GLUTAMIC ACID Y-CYCLOHEXYLESTER;(R)-2-((tert-Butoxycarbonyl)amino)-5-(cyclohexyloxy)-5-oxopentanoic acid

Chemical Property of BOC-D-GLU(OCHEX)-OH

Chemical Property:

• Vapor Pressure: 1.82E-11mmHg at 25°C
• Refractive Index: 1.497
• Boiling Point: 502.6 °C at 760 mmHg
• Flash Point: 257.8 °C
• PSA: 101.93000
• Density: 1.16 g/cm³
• LogP: 3.01130
• Storage Temp.: Store at RT.

Purity/Quality:

98%min ^*data from raw suppliers

Boc-D-glutamic acid γ-cyclohexyl ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BOC-D-GLU(OCHEX)-OH

There total 5 articles about BOC-D-GLU(OCHEX)-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

→ N-α-tert-butyloxycarbonyl-glutamic acid, γ-cyclohexyl ester (73821-97-3,133464-27-4)

Guidance literature:

With trimethyltin(IV) hydroxide; In 1,2-dichloro-ethane; for 10h; Heating;

DOI:10.1016/S0040-4020(98)00805-9

Reference yield: 97.0%

→ N-α-tert-butyloxycarbonyl-glutamic acid, γ-cyclohexyl ester (73821-97-3,133464-27-4)

Guidance literature:

With trimethyltin(IV) hydroxide; In 1,2-dichloro-ethane; for 12h; Heating;

DOI:10.1016/S0040-4020(98)00805-9

Reference yield:

L-glutamic acid (56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6) → N-α-tert-butyloxycarbonyl-glutamic acid, γ-cyclohexyl ester (73821-97-3,133464-27-4)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂SO₄ / diethyl ether / 2 h / 70 °C

2: 1,1,3,3-tetramethylguanidine / dimethylformamide / 12 h / Ambient temperature

With sulfuric acid; N,N,N',N'-tetramethylguanidine; In diethyl ether; N,N-dimethyl-formamide;

DOI:10.1055/s-1992-26108

upstream raw materials:

di-tert-butyl dicarbonate

γ-cyclohexyl L-glutamate

L-glutamic acid

cyclohexanol

Refernces

• 1、 Toth,Penke. "An improved method for the preparation of ω-cyclohexyl esters of aspartic and glutamic acid". . p. 361 - 362. Retrieved 2007/10/02.