C₉H₈FIO

Base Information

• Chemical Name: C₉H₈FIO
• CAS No.: 1334314-96-3
• Molecular Formula: C₉H₈FIO
• Molecular Weight: 278.065
• Mol file: 1334314-96-3.mol

Synonyms:C₉H₈FIO

Chemical Property of C₉H₈FIO

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of C₉H₈FIO

There total 2 articles about C₉H₈FIO which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(3-fluoro-4-methoxyphenyl)ethanone (455-91-4) → C9H8FIO (1334314-96-3)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; hydrazine / ethanol / Reflux; Inert atmosphere

2: iodine; triethylamine / Inert atmosphere

With iodine; triethylamine; hydrazine; In ethanol;

DOI:10.1021/ol3010112

Reference yield:

C9H11FN2O → C9H8FIO (1334314-96-3)

Guidance literature:

With iodine; triethylamine; Inert atmosphere;

DOI:10.1021/ol3010112

Reference yield: 95.0%

C9H8FIO (1334314-96-3) + 4-fluorophenylmagnesium chloride (130387-74-5) → 2-fluoro-4-(1-(4-fluorophenyl)vinyl)-1-methoxybenzene (1379793-81-3)

Guidance literature:

With iron(III) chloride; copper(I) thiophene-2-carboxylate; In tetrahydrofuran; at -20 - 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/ol3010112

upstream raw materials:

1-(3-fluoro-4-methoxyphenyl)ethanone

Downstream raw materials:

2-[1-(3-fluoro-4-methoxyphenyl)vinyl]-1-(N-methylsulfonyl)-1H-indole

5-(1-(3-fluoro-4-methoxyphenyl)vinyl)-1,2,3-trimethoxybenzene

2-fluoro-4-(1-(4-fluorophenyl)vinyl)-1-methoxybenzene

2-fluoro-1-methoxy-4-(3-phenylprop-1-en-2-yl)benzene

Refernces