4-BROMO-2-FLUORO-6-NITROANISOLE

Base Information

• Chemical Name: 4-BROMO-2-FLUORO-6-NITROANISOLE
• CAS No.: 74266-66-3
• Molecular Formula: C7H5BrFNO3
• Molecular Weight: 250.024
• Hs Code.: 29093090
• Mol file: 74266-66-3.mol

Synonyms:2-Fluoro-4-bromo-6-nitroanisole;4-Bromo-2-fluoro-6-nitroanisole;5-Bromo-1-fluoro-2-methoxy-3-nitrobenzene;4-Bromo-2-fluoro-6-nitrophenyl methyl ether;

Chemical Property of 4-BROMO-2-FLUORO-6-NITROANISOLE

Chemical Property:

• Vapor Pressure: 0.00119mmHg at 25°C
• Melting Point: 58-60 °C(lit.)
• Refractive Index: 1.56
• Boiling Point: 309.1 °C at 760 mmHg
• Flash Point: 140.7 °C
• PSA: 55.05000
• Density: 1.716 g/cm³
• LogP: 3.02820
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Bromo-2-fluoro-6-nitroanisole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-BROMO-2-FLUORO-6-NITROANISOLE

There total 4 articles about 4-BROMO-2-FLUORO-6-NITROANISOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-fluorophenol (367-12-4) → bromo-4 fluoro-2 nitro-6 anisole (74266-66-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 49 percent / liquid nitrogen dioxide / pentane / 35 min, 0 deg C then 20 min, room temperature

2: 98.5 percent / hydrogen / 5percent Pd/C / ethyl acetate / 24 h / 760 Torr

3: 2., HBr, CuBr

4: 98 percent / liquide nitrogen dioxide / pentane / 35 min, 0 deg C then 20 min, room temperature

With hydrogen; Nitrogen dioxide; palladium on activated charcoal; In ethyl acetate; pentane;

Reference yield:

2-fluoro-4-nitrophenol (403-19-0) → bromo-4 fluoro-2 nitro-6 anisole (74266-66-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 98.5 percent / hydrogen / 5percent Pd/C / ethyl acetate / 24 h / 760 Torr

2: 2., HBr, CuBr

3: 98 percent / liquide nitrogen dioxide / pentane / 35 min, 0 deg C then 20 min, room temperature

With hydrogen; Nitrogen dioxide; palladium on activated charcoal; In ethyl acetate; pentane;

Reference yield:

4-bromo-2-fluorophenol (2105-94-4) → bromo-4 fluoro-2 nitro-6 anisole (74266-66-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / liquide nitrogen dioxide / pentane / 35 min, 0 deg C then 20 min, room temperature

With Nitrogen dioxide; In pentane;

upstream raw materials:

4-bromo-2-fluorophenol

2-fluorophenol

2-fluoro-4-nitrophenol

4-amino-2-fluorophenol

Downstream raw materials:

2-fluoro-4-methyl-6-nitroanisole

5-bromo-3-fluoro-2-methoxyaniline

fluoro-3 methoxy-2 benzaldehhyde

3-fluorosalicylaldehyde

Refernces