1-acetyl-N-(3-chloro-4-methylphenyl)-N-(3-(3-exo-(3-isopropyl-5-methyl-4-hydro-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl)propyl)-4-piperidinylcarboxamide

Base Information

• Chemical Name: 1-acetyl-N-(3-chloro-4-methylphenyl)-N-(3-(3-exo-(3-isopropyl-5-methyl-4-hydro-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl)propyl)-4-piperidinylcarboxamide
• CAS No.: 1221569-04-5
• Molecular Formula: C₃₁H₄₅ClN₆O₂
• Molecular Weight: 569.19
• Mol file: 1221569-04-5.mol

Synonyms:1-acetyl-N-(3-chloro-4-methylphenyl)-N-(3-(3-exo-(3-isopropyl-5-methyl-4-hydro-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl)propyl)-4-piperidinylcarboxamide

Chemical Property of 1-acetyl-N-(3-chloro-4-methylphenyl)-N-(3-(3-exo-(3-isopropyl-5-methyl-4-hydro-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl)propyl)-4-piperidinylcarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-acetyl-N-(3-chloro-4-methylphenyl)-N-(3-(3-exo-(3-isopropyl-5-methyl-4-hydro-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl)propyl)-4-piperidinylcarboxamide

There total 9 articles about 1-acetyl-N-(3-chloro-4-methylphenyl)-N-(3-(3-exo-(3-isopropyl-5-methyl-4-hydro-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl)propyl)-4-piperidinylcarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

UK-408027 (423165-07-5) + 1-acetyl-piperidine-4-carboxylic acid (3-chloro-4-methyl-phenyl)-(3-chloro-propyl)-amide (333985-70-9) → 1-acetyl-N-(3-chloro-4-methylphenyl)-N-(3-(3-exo-(3-isopropyl-5-methyl-4-hydro-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl)propyl)-4-piperidinylcarboxamide (1221569-04-5)

Guidance literature:

With triethylamine; In acetonitrile; for 24h; Reflux;

Reference yield:

8-benzyl-8-azabicyclo[3.2.1] octan-3-one oxime (76272-34-9) → 1-acetyl-N-(3-chloro-4-methylphenyl)-N-(3-(3-exo-(3-isopropyl-5-methyl-4-hydro-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl)propyl)-4-piperidinylcarboxamide (1221569-04-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium; pentan-1-ol / 2 h / Reflux

2.1: sodium carbonate / dichloromethane; water / 2 h / 0 - 20 °C

3.1: phosphorus pentachloride / dichloromethane / 2 h / 10 - 20 °C / Cooling with ice

3.2: 10 - 20 °C

3.3: pH 12 / Cooling with ice

4.1: ammonium formate / palladium 10% on activated carbon / ethanol / 12 h / Reflux; Inert atmosphere

5.1: triethylamine / acetonitrile / 24 h / Reflux

With pentan-1-ol; phosphorus pentachloride; ammonium formate; sodium; sodium carbonate; triethylamine; palladium 10% on activated carbon; In ethanol; dichloromethane; water; acetonitrile;

Reference yield:

acetonedicarboxylic acid (542-05-2) → 1-acetyl-N-(3-chloro-4-methylphenyl)-N-(3-(3-exo-(3-isopropyl-5-methyl-4-hydro-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl)propyl)-4-piperidinylcarboxamide (1221569-04-5)

Guidance literature:

Multi-step reaction with 7 steps

1.1: hydrogenchloride; water / 1 h / Reflux

1.2: 6 h / 0 - 50 °C

1.3: pH 12

2.1: hydroxylamine hydrochloride; pyridine / ethanol / 18 h / Reflux

3.1: sodium; pentan-1-ol / 2 h / Reflux

4.1: sodium carbonate / dichloromethane; water / 2 h / 0 - 20 °C

5.1: phosphorus pentachloride / dichloromethane / 2 h / 10 - 20 °C / Cooling with ice

5.2: 10 - 20 °C

5.3: pH 12 / Cooling with ice

6.1: ammonium formate / palladium 10% on activated carbon / ethanol / 12 h / Reflux; Inert atmosphere

7.1: triethylamine / acetonitrile / 24 h / Reflux

With pyridine; hydrogenchloride; pentan-1-ol; phosphorus pentachloride; hydroxylamine hydrochloride; water; ammonium formate; sodium; sodium carbonate; triethylamine; palladium 10% on activated carbon; In ethanol; dichloromethane; water; acetonitrile;

upstream raw materials:

8-benzyl-8-azabicyclo[3.2.1] octan-3-one oxime

acetonedicarboxylic acid

3-chloro-p-toluidine

N-benzyltropinone

Refernces