Cbz-DL-α-methylglutamic acid

Base Information

• Chemical Name: Cbz-DL-α-methylglutamic acid
• CAS No.: 202271-71-4
• Molecular Formula: C₁₄H₁₇NO₆
• Molecular Weight: 295.292
• Mol file: 202271-71-4.mol

Synonyms:Cbz-DL-α-methylglutamic acid

Chemical Property of Cbz-DL-α-methylglutamic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cbz-DL-α-methylglutamic acid

There total 2 articles about Cbz-DL-α-methylglutamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-methylglutamic acid (71-90-9,470-51-9) + benzyl chloroformate (501-53-1,94274-21-2) → Cbz-DL-α-methylglutamic acid (202271-71-4)

Guidance literature:

With sodium hydroxide; In water; at 0 - 20 ℃; for 3.5h; pH=11; Stirring at room temperature;

Reference yield:

→ Cbz-DL-α-methylglutamic acid (202271-71-4)

Guidance literature:

With water; magnesium oxide; benzyl chloroformate; Reagens 4: Toluol;

DOI:10.1021/ja01608a045

Reference yield:

Cbz-DL-α-methylglutamic acid (202271-71-4) → 2-methylglutamic acid (71-90-9,470-51-9)

Guidance literature:

With ethylenediaminetetraacetic acid; phenylmethylsulphonyl fluoride; water; In aq. phosphate buffer; at 30 ℃; Reagent/catalyst; Kinetics; Microbiological reaction; Enzymatic reaction;

DOI:10.1016/j.molcatb.2012.03.005

upstream raw materials:

2-methylglutamic acid

benzyl chloroformate

Downstream raw materials:

2-methylglutamic acid

Refernces

• 1、 -. "Substituted 2(2,6-dioxopiperidin-3-yl)isoindolines". Page column 10. . Retrieved 2008/06/13.