2-(4-Hydroxy-3-nitrophenyl)-4-methyl-5-thiazolecarboxylic acid ethyl ester

Base Information

• Chemical Name: 2-(4-Hydroxy-3-nitrophenyl)-4-methyl-5-thiazolecarboxylic acid ethyl ester
• CAS No.: 144060-67-3
• Molecular Formula: C13H12N2O5S
• Molecular Weight: 308.315
• Hs Code.: 2934100090
• Mol file: 144060-67-3.mol

Synonyms:2-(4-Hydroxy-3-nitrophenyl)-4-methyl-5-thiazolecarboxylic acid ethyl ester;Ethyl 2-(4-hydroxy-3-nitrophenyl)-4-methyl-5-thiazolecarbonate;Ethyl 2-(4-hydroxy-3-nitrophenyl)-4-methylthiazole-5-carboxylate

Chemical Property of 2-(4-Hydroxy-3-nitrophenyl)-4-methyl-5-thiazolecarboxylic acid ethyl ester

Chemical Property:

• Vapor Pressure: 7.95E-09mmHg at 25°C
• Refractive Index: 1.622
• Boiling Point: 453.044 °C at 760 mmHg
• Flash Point: 227.793 °C
• PSA: 133.48000
• Density: 1.412 g/cm³
• LogP: 3.43220
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl 2-(4-hydroxy-3-nitrophenyl)-4-methylthiazole-5-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-Hydroxy-3-nitrophenyl)-4-methyl-5-thiazolecarboxylic acid ethyl ester

There total 3 articles about 2-(4-Hydroxy-3-nitrophenyl)-4-methyl-5-thiazolecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

4-hydroxy-3-nitrobenzthioamide + ethyl (2-chloroaceto)acetate (638-07-3) → ethyl 2-(4-hydroxy-3-nitrophenyl)-4-methyl-5-thiazolecarboxylate (144060-67-3)

Guidance literature:

In ethanol;

Reference yield:

(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester) (161797-99-5) → ethyl 2-(4-hydroxy-3-nitrophenyl)-4-methyl-5-thiazolecarboxylate (144060-67-3)

Guidance literature:

With copper(II) nitrate; N,N-dimethyl-formamide; trichlorophosphate; In acetonitrile; at 25 - 45 ℃; for 0.5h; Reagent/catalyst; Solvent; Temperature;

Reference yield:

4-cyanophenol (767-00-0) → ethyl 2-(4-hydroxy-3-nitrophenyl)-4-methyl-5-thiazolecarboxylate (144060-67-3)

Guidance literature:

Multi-step reaction with 3 steps

1: O,O-Diethyl hydrogen phosphorodithioate / water / 3 h / 50 °C

2: ethanol / 3 h / 65 - 70 °C

3: copper(II) nitrate; N,N-dimethyl-formamide; trichlorophosphate / acetonitrile / 0.5 h / 25 - 45 °C

With copper(II) nitrate; O,O-Diethyl hydrogen phosphorodithioate; N,N-dimethyl-formamide; trichlorophosphate; In ethanol; water; acetonitrile;

upstream raw materials:

ethyl (2-chloroaceto)acetate

4-cyanophenol

(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)

Downstream raw materials:

ethyl 2-(3-chloro-4-hydroxyphenyl)-4-methyl-5-thiazolecarboxylate

2-(3-bromo-4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester

Refernces

• 1、 -. "2-arylthiazole derivatives and pharmaceutical composition thereof". . . Retrieved 2008/06/13.