Technology Process of 1α-benzyloxy-12α,13α-epoxypicras-14-ene-2,16-dione
There total 1 articles about 1α-benzyloxy-12α,13α-epoxypicras-14-ene-2,16-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
thionyl chloride;
In
pyridine;
at 0 ℃;
DOI:10.1021/jo9718962
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: 92 percent / H2 / Pd/C / ethanol / 48 h / 20 °C
2.1: DIBAL-H / tetrahydrofuran; hexane / 0.5 h / -78 °C
3.1: conc. HCl / 1 h / 0 °C
4.1: DMSO; TFAA; Et3N / CH2Cl2 / -78 - 20 °C
5.1: 7 mg / NaH / dimethylformamide / 1 h / -20 °C
6.1: LDA / tetrahydrofuran / 0.5 h / -78 °C
6.2: MoOPH / tetrahydrofuran / -78 - 0 °C
7.1: DMSO; TFAA; Et3N / CH2Cl2 / -78 - 20 °C
8.1: 5.7 mg / NaH / dimethylformamide / 0.67 h / -20 °C
9.1: AcOH / H2O / 0.42 h / Heating
10.1: 3.8 mg / Ag2CO3 on Celite / benzene / 2.5 h / Heating
With
hydrogenchloride; hydrogen; sodium hydride; diisobutylaluminium hydride; acetic acid; dimethyl sulfoxide; triethylamine; silver carbonate; trifluoroacetic anhydride; lithium diisopropyl amide;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; benzene;
1.1: Catalytic hydrogenation / 2.1: Reduction / 3.1: Methylation / 4.1: Swern oxidation / 5.1: Methylation / 6.1: Deprotonation / 6.2: Hydroxylation / 7.1: Swern oxidation / 8.1: Methylation / 9.1: Hydrolysis / 10.1: Oxidation;
DOI:10.1021/jo000877g
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 92 percent / H2 / Pd/C / ethanol / 48 h / 20 °C
2.1: DIBAL-H / tetrahydrofuran; hexane / 0.5 h / -78 °C
3.1: conc. HCl / 1 h / 0 °C
4.1: DMSO; TFAA; Et3N / CH2Cl2 / -78 - 20 °C
5.1: 7 mg / NaH / dimethylformamide / 1 h / -20 °C
6.1: LDA / tetrahydrofuran / 0.5 h / -78 °C
6.2: MoOPH / tetrahydrofuran / -78 - 0 °C
7.1: DMSO; TFAA; Et3N / CH2Cl2 / -78 - 20 °C
8.1: 5.7 mg / NaH / dimethylformamide / 0.67 h / -20 °C
With
hydrogenchloride; hydrogen; sodium hydride; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; trifluoroacetic anhydride; lithium diisopropyl amide;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide;
1.1: Catalytic hydrogenation / 2.1: Reduction / 3.1: Methylation / 4.1: Swern oxidation / 5.1: Methylation / 6.1: Deprotonation / 6.2: Hydroxylation / 7.1: Swern oxidation / 8.1: Methylation;
DOI:10.1021/jo000877g
