(2,4-Dichlorophenoxy)acetyl chloride

Base Information

• Chemical Name: (2,4-Dichlorophenoxy)acetyl chloride
• CAS No.: 774-74-3
• Molecular Formula: C8H5Cl3O2
• Molecular Weight: 239.485
• Hs Code.: 2918999090
• European Community (EC) Number: 212-268-8
• DSSTox Substance ID: DTXSID50967553
• Nikkaji Number: J99.845A
• Wikidata: Q82950154
• Mol file: 774-74-3.mol

Synonyms:(2,4-Dichlorophenoxy)acetyl chloride;774-74-3;2-(2,4-dichlorophenoxy)acetyl chloride;2,4-Dichlorophenoxyacetyl chloride;Acetyl chloride, (2,4-dichlorophenoxy)-;2,4-dichlorophenoxy acetyl chloride;EINECS 212-268-8;2,4-Dichlorophenoxyacetic acid chloride;4-Dich;(2,4-Dichloro-phenoxy)-acetyl chloride;SCHEMBL2538911;DTXSID50967553;2,4 dichlorophenoxyacetyl chloride;BCP34190;STR07073;BBL013924;MFCD00045225;STL195420;(2,4-dichloro-phenoxy)-acetylchloride;2-(2,4-dichlorophenoxy)acetylchloride;AKOS000103942;2,4-dichlorophenoxy-acetic acid chloride;2-(2,4-dichlorophenoxy)ethanoyl chloride;CS-0238203;FT-0608397;FT-0683329;EN300-19132;(2,4-Dichlorophenoxy)acetyl chloride, AldrichCPR;A829372;AG-205/25006780;W-109604;F2190-0094

Chemical Property of (2,4-Dichlorophenoxy)acetyl chloride

Chemical Property:

• Vapor Pressure: 0.00168mmHg at 25°C
• Refractive Index: 1.556
• Boiling Point: 296.4 °C at 760 mmHg
• Flash Point: 126.3 °C
• PSA: 26.30000
• Density: 1.475 g/cm³
• LogP: 3.13760
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 237.935512
• Heavy Atom Count: 13
• Complexity: 186

Purity/Quality:

99%, ^*data from raw suppliers

(2,4-Dichlorophenoxy)acetylChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1Cl)Cl)OCC(=O)Cl

Technology Process of (2,4-Dichlorophenoxy)acetyl chloride

There total 9 articles about (2,4-Dichlorophenoxy)acetyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2,4-Dichlorophenoxyacetic acid (94-75-7,89300-30-1) → 2-(2,4-dichlorophenoxy)acetyl chloride (774-74-3)

Guidance literature:

With thionyl chloride; at 100 ℃; for 5h;

Reference yield:

5-[2-chloro-4-(trifluoromethyl)phenoxy]benzoyl chloride → 2-hydroxyethyl 5-(2-chloro-4-trifluoromethyl phenoxy)-2-nitrobenzoate (77207-06-8) + 2-(2,4-dichlorophenoxy)acetyl chloride (774-74-3)

Guidance literature:

With triethylamine; In dichloromethane; ethylene glycol;

Reference yield:

2,4-dichlorophenol (120-83-2,40477-79-0) → 2-(2,4-dichlorophenoxy)acetyl chloride (774-74-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / NaOH / H₂O / 3 h / 110 - 120 °C

2: SOCl₂

With sodium hydroxide; thionyl chloride; In water;

DOI:10.1023/A:1012387131029

upstream raw materials:

2,4-Dichlorophenoxyacetic acid

2,4-dichlorophenol

sodium 2,4-dichlorophenolate

ethyl 2,4-dichlorophenoxyacetate

Downstream raw materials:

(2,4-dichloro-phenoxy)-acetic acid-(2-hydroxy-ethylamide)

(2,4-dichloro-phenoxy)-thioacetic acid S-phenyl ester

(2,4-dichloro-phenoxy)-acetic acid-(2-methoxy-phenyl ester)

(2,4-dichloro-phenoxy)-acetic acid-(4-nitro-anilide)

Refernces

• 1、 Almehizia, Abdulrahman A.,Amr, Abd El-Galil E.,El-Sayed, Amira A.,Nossier, Eman S.. "Design, synthesis, anticancer evaluation and molecular docking study of novel 2,4-dichlorophenoxymethyl-based derivatives linked to nitrogenous heterocyclic ring systems as potential CDK-2 inhibitors". . . Retrieved 2021/08/23.
• 2、 Lei, Kang,Li, Pan,Yang, Xue-Fang,Wang, Shi-Ben,Wang, Xue-Kun,Hua, Xue-Wen,Sun, Bin,Ji, Lu-Sha,Xu, Xiao-Hua. "Design and Synthesis of Novel 4-Hydroxyl-3-(2-phenoxyacetyl)-pyran-2-one Derivatives for Use as Herbicides and Evaluation of Their Mode of Action". . p. 10489 - 10497. Retrieved 2019/10/02.