4-BROMO-2,3-DIMETHYLANILINE

Base Information

• Chemical Name: 4-BROMO-2,3-DIMETHYLANILINE
• CAS No.: 22364-25-6
• Molecular Formula: C8H10BrN
• Molecular Weight: 200.078
• Hs Code.: 2921430090
• Mol file: 22364-25-6.mol

Synonyms:4-Bromo-2,3-dimethylaniline 98%;

Chemical Property of 4-BROMO-2,3-DIMETHYLANILINE

Chemical Property:

• Vapor Pressure: 0.009mmHg at 25°C
• Melting Point: 215-217 °C
• Refractive Index: 1.597
• Boiling Point: 265.519 °C at 760 mmHg
• PKA: 3.87±0.10(Predicted)
• Flash Point: 114.382 °C
• PSA: 26.02000
• Density: 1.424 g/cm³
• LogP: 3.22930
• Storage Temp.: Keep Cold

Purity/Quality:

98%min ^*data from raw suppliers

4-Bromo-2,3-dimethylaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-BROMO-2,3-DIMETHYLANILINE

There total 4 articles about 4-BROMO-2,3-DIMETHYLANILINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-bromo-2,3-dimethylacetanilide (22369-96-6) → 4-bromo-2,3-dimethylaniline (22364-25-6)

Guidance literature:

With hydrogenchloride; In ethanol; Heating;

DOI:10.1021/jo010858m

Reference yield: 82.0%

2,3-Dimethylaniline (87-59-2) → 4-bromo-2,3-dimethylaniline (22364-25-6)

Guidance literature:

With N-Bromosuccinimide; In N,N-dimethyl-formamide; at 20 ℃; for 5h;

Reference yield:

N-(2,3-dimethylphenyl)acetamide (134-98-5) → 4-bromo-2,3-dimethylaniline (22364-25-6)

Guidance literature:

Multi-step reaction with 2 steps

1: NBS / CCl₄

2: aq. HCl

With hydrogenchloride; N-Bromosuccinimide; In tetrachloromethane;

upstream raw materials:

2,3-Dimethylaniline

4-bromo-2,3-dimethylacetanilide

N-(2,3-dimethylphenyl)acetamide

Downstream raw materials:

N,N,N',N'-tetramethylbenzidine

2,3-dimethylbromobenzene

1,4-dibromo-2,3-dimethylbenzene

1-chloro-4-bromo-2,3-dimethylbenzene

Refernces

• 1、 -. "Synthesis method of topramezone key intermediate". Paragraph 0039-0043. . Retrieved 2021/02/06.
• 2、 -. "METHODS OF PROMOTING BETA CELL PROLIFERATION". Paragraph 0262. . Retrieved 2018/06/30.