(S)-clopidogrel hydrogen sulfate

Base Information

• Chemical Name: (S)-clopidogrel hydrogen sulfate
• CAS No.: 1233025-55-2
• Molecular Formula: C₁₅H₁₄ClNO₂S*H₂O₄S
• Molecular Weight: 405.88
• Mol file: 1233025-55-2.mol

Synonyms:(S)-clopidogrel hydrogen sulfate

Chemical Property of (S)-clopidogrel hydrogen sulfate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (S)-clopidogrel hydrogen sulfate

There total 4 articles about (S)-clopidogrel hydrogen sulfate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(S)-(+)-clopidogrel (113665-84-2,94188-84-8) → (S)-clopidogrel hydrogen sulfate (1233025-55-2)

Guidance literature:

With sulfuric acid; In 1,2-dimethoxyethane; at 0 - 5 ℃; for 12h;

Reference yield:

diethylether (DEE) + (S)-(+)-clopidogrel (113665-84-2,94188-84-8) → (S)-clopidogrel hydrogen sulfate (1233025-55-2)

Guidance literature:

With sulfuric acid; In isopropyl alcohol;

Reference yield:

tert-butylmethyl ether (MTBE) + (S)-(+)-clopidogrel (113665-84-2,94188-84-8) → (S)-clopidogrel hydrogen sulfate (1233025-55-2)

Guidance literature:

With sulfuric acid; In isopropyl alcohol;

upstream raw materials:

(S)-(+)-clopidogrel

Downstream raw materials:

(S)-(+)-clopidogrel bisulfate

Refernces

• 1、 -. "Novel crystal forms III, IV, V, and novel amorphous form of clopidogrel hydrogensulfate, processes for their preparation, processes for the preparation of form I, compositions containing the new forms and methods of administering the new forms". . . Retrieved 2008/06/13.