1-(4-Nitrophenyl)-1H-pyrazole

Base Information

• Chemical Name: 1-(4-Nitrophenyl)-1H-pyrazole
• CAS No.: 3463-30-7
• Molecular Formula: C9H7 N3 O2
• Molecular Weight: 189.173
• Hs Code.: 2933199090
• Mol file: 3463-30-7.mol

Synonyms:Pyrazole,1-(p-nitrophenyl)- (6CI,7CI,8CI);1-(4-Nitrophenyl)-1H-pyrazole;1-(p-Nitrophenyl)pyrazole;1-(4-Nitrophenyl)pyrazole;1-(4-nitrophenyl)-1h-pyrazole 95%;

Chemical Property of 1-(4-Nitrophenyl)-1H-pyrazole

Chemical Property:

• Melting Point: 168.5-169 °C
• Boiling Point: 331.8 °C at 760 mmHg
• PKA: -0.78±0.10(Predicted)
• Flash Point: 154.5 °C
• PSA: 63.64000
• Density: 1.33g/cm³
• LogP: 2.30370
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98.00% ^*data from raw suppliers

1-(4-Nitrophenyl)-1H-pyrazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-Nitrophenyl)-1H-pyrazole

There total 20 articles about 1-(4-Nitrophenyl)-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

NH-pyrazole (288-13-1) + p-nitrobenzene iodide (636-98-6) → 1-(4-nitrophenyl)pyrazole (3463-30-7)

Guidance literature:

With copper(I) oxide; potassium phosphate; N¹,N²-bis(furan-2-ylmethyl)oxalamide; In acetonitrile; at 80 ℃; for 24h;

DOI:10.1002/adsc.201700026

Reference yield: 99.0%

NH-pyrazole (288-13-1) + para-nitrophenyl bromide (586-78-7) → 1-(4-nitrophenyl)pyrazole (3463-30-7)

Guidance literature:

With 0.21C₁₄H₈Cl₂CuN₂O₄^(2-)*2.79C₈H₅NO₄^(2-)*Zn₄O⁽⁶⁺⁾; caesium carbonate; In dimethyl sulfoxide; at 90 ℃; for 20h; Catalytic behavior; Inert atmosphere;

DOI:10.1002/cctc.201400056

Reference yield: 98.0%

NH-pyrazole (288-13-1) + 4-chlorobenzonitrile (100-00-5) → 1-(4-nitrophenyl)pyrazole (3463-30-7)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 4h; Inert atmosphere;

DOI:10.1039/c6ra08664k

upstream raw materials:

ISOXAZOLE

malondialdehyde bis(diethyl acetal)

4-nitrophenylhydrazine hydrochloride

1-phenylpyrazole

Downstream raw materials:

1-(4-nitrophenyl)-1H-pyrazole-4-carboxylic acid

methyl 1-(4-nitrophenyl)-1H-pyrazole-4-carboxylate

Refernces

• 1、 Farrokhi, Alireza,Rouzifar, Majid,Sansano, José Miguel,Sobhani, Sara. "Fe-MIL-101 modified by isatin-Schiff-base-Co: a heterogeneous catalyst for C-C, C-O, C-N, and C-P cross coupling reactions". . p. 19963 - 19976. Retrieved 2021/11/12.
• 2、 Zahedi, Razieh,Asadi, Zahra,Firuzabadi, Fahimeh Dehghani. "A Highly Active, Recyclable and Cost-Effective Magnetic Nanoparticles Supported Copper Catalyst for N-arylation Reaction". . p. 65 - 73. Retrieved 2019/08/22.