3‐(methylthio)‐2‐naphthaldehyde

Base Information

• Chemical Name: 3‐(methylthio)‐2‐naphthaldehyde
• CAS No.: 364064-72-2
• Molecular Formula: C₁₂H₁₀OS
• Molecular Weight: 202.277
• Mol file: 364064-72-2.mol

Synonyms:3‐(methylthio)‐2‐naphthaldehyde

Chemical Property of 3‐(methylthio)‐2‐naphthaldehyde

Chemical Property:

Purity/Quality:

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Technology Process of 3‐(methylthio)‐2‐naphthaldehyde

There total 1 articles about 3‐(methylthio)‐2‐naphthaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

3-bromo-2-naphthalenecarboxaldehyde (89005-11-8) + sodium thiomethoxide (5188-07-8) → 3‐(methylthio)‐2‐naphthaldehyde (364064-72-2)

Guidance literature:

In water; N,N-dimethyl-formamide; at 0 - 20 ℃; for 16h; Inert atmosphere;

DOI:10.1002/adsc.202101099

Reference yield: 35.0%

3‐(methylthio)‐2‐naphthaldehyde (364064-72-2) + 3-phenyl-5H-1,4,2-dioxazol-5-one (19226-36-9) → N‐benzoyl‐3‐(methylthio)‐2‐naphthamide

Guidance literature:

With silver hexafluoroantimonate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; sodium acetate; In 1,2-dichloro-ethane; at 25 - 80 ℃; for 20.5h; chemoselective reaction; Schlenk technique; Inert atmosphere;

DOI:10.1002/adsc.202101099

Reference yield:

3‐(methylthio)‐2‐naphthaldehyde (364064-72-2) → dinaphtho[2,3-b:2′,3′-f ]thieno-[3,2-b]thiophene (935280-42-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / zinc; TiCl₄ / tetrahydrofuran / 10 h / Heating

2: 85 percent / iodine / CHCl₃ / 21 h / Heating

With iodine; titanium tetrachloride; zinc; In tetrahydrofuran; chloroform; 1: McMurry coupling;

DOI:10.1021/ja068429z

upstream raw materials:

3-bromo-2-naphthalenecarboxaldehyde

sodium thiomethoxide

Downstream raw materials:

dinaphtho[2,3-b:2′,3′-f ]thieno-[3,2-b]thiophene

Refernces