3-(1-adamantyl)-4-methoxybenzoic acid

Base Information

• Chemical Name: 3-(1-adamantyl)-4-methoxybenzoic acid
• CAS No.: 104224-62-6
• Molecular Formula: C₁₈H₂₂O₃
• Molecular Weight: 286.371
• Mol file: 104224-62-6.mol

Synonyms:3-(1-adamantyl)-4-methoxybenzoic acid

Chemical Property of 3-(1-adamantyl)-4-methoxybenzoic acid

Chemical Property:

• Melting Point: 245-246 °C
• Boiling Point: 450.9±38.0 °C(Predicted)
• PKA: 4.51±0.10(Predicted)
• Density: 1.219±0.06 g/cm3(Predicted)

Purity/Quality:

98%min ^*data from raw suppliers

3-(1-Adamantyl)-4-methoxybenzoic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(1-adamantyl)-4-methoxybenzoic acid

There total 7 articles about 3-(1-adamantyl)-4-methoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

methyl 3-(1-adamantyl)-4-methoxybenzoate → 3-(1-adamantyl)-4-methoxybenzoic acid (104224-62-6)

Guidance literature:

With water; sodium hydroxide; In tetrahydrofuran; ethanol; for 4h; Reflux;

Reference yield:

1-acetyloxyadamantane (22635-62-7) + 4-methoxybenzoic acid (100-09-4) → 3-(1-adamantyl)-4-methoxybenzoic acid (104224-62-6)

Guidance literature:

With sulfuric acid; In ethanol; n-heptane;

Reference yield:

ethylene dibromide (106-93-4) + 2-(1-adamantyl)-4-bromoanisole (104224-63-7) → 3-(1-adamantyl)-4-methoxybenzoic acid (104224-62-6)

Guidance literature:

In tetrahydrofuran;

upstream raw materials:

carbon dioxide

2-(1-adamantyl)-4-bromoanisole

4-bromo-phenol

1-adamanthanol

Downstream raw materials:

3-adamantane-1-yl-N-(2,4-dihydroxybenzyl)-4-methoxybenzoic acid amide

3-adamantan-1-yl-N-(3,4-dihydroxybenzyl)-4-methoxy-benzoic acid amide

3-adamantan-1-yl-N-[2-(3,4-dihydroxyphenyl)-ethyl]-4-methoxy-benzoic acid amide

3-adamantan-1-yl-N-[2-(4-hydroxyphenyl)-ethyl]-4-methoxy-benzoic acid amide

Refernces

• 1、 Baek, Heung Soo,Hong, Yong Deog,Lee, Chang Seok,Rho, Ho Sik,Shin, Song Seok,Park, Young-Ho,Joo, Yung Hyup. "Adamantyl N-benzylbenzamide: New series of depigmentation agents with tyrosinase inhibitory activity". scheme or table. p. 2110 - 2113. Retrieved 2012/04/18.
• 2、 -. "S1P RECEPTORS MODULATORS". Page/Page column 85; 86. . Retrieved 2010/04/30.