anhydrous 2-(4'-bromo[1,1'-biphenyl]-4-yl)-2-methyl-1,3-dioxolane

Base Information

• Chemical Name: anhydrous 2-(4'-bromo[1,1'-biphenyl]-4-yl)-2-methyl-1,3-dioxolane
• CAS No.: 107967-74-8
• Molecular Formula: C₁₆H₁₅BrO₂
• Molecular Weight: 319.198
• Mol file: 107967-74-8.mol

Synonyms:anhydrous 2-(4'-bromo[1,1'-biphenyl]-4-yl)-2-methyl-1,3-dioxolane

Chemical Property of anhydrous 2-(4'-bromo[1,1'-biphenyl]-4-yl)-2-methyl-1,3-dioxolane

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of anhydrous 2-(4'-bromo[1,1'-biphenyl]-4-yl)-2-methyl-1,3-dioxolane

There total 1 articles about anhydrous 2-(4'-bromo[1,1'-biphenyl]-4-yl)-2-methyl-1,3-dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-bromo-4'-acetylbiphenyl (5731-01-1) + ethylene glycol (107-21-1) → anhydrous 2-(4'-bromo[1,1'-biphenyl]-4-yl)-2-methyl-1,3-dioxolane (107967-74-8)

Guidance literature:

toluene-4-sulfonic acid; In benzene;

DOI:10.1021/ja00221a032

Reference yield: 94.0%

anhydrous 2-(4'-bromo[1,1'-biphenyl]-4-yl)-2-methyl-1,3-dioxolane (107967-74-8) → 4'-(2-methyl-1,3-dioxolan-2-yl)[1,1'-biphenyl]-4-thiol

Guidance literature:

With sodium thiomethoxide; In N,N-dimethyl acetamide; acetic acid;

Reference yield:

anhydrous 2-(4'-bromo[1,1'-biphenyl]-4-yl)-2-methyl-1,3-dioxolane (107967-74-8) → 1-[4'-((2R,3R)-2-Isopropyl-3-methyl-aziridine-1-carbonyl)-biphenyl-4-yl]-ethanone (114691-99-5,114692-00-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) Mg / 1.) THF, reflux, 12 h; 2.) room temp.

2: 1.) triethylamine, ethyl chloroformate; 2.) NaN₃ / 1.) DMF, 30 min; 2.) H₂O, acetone, 20 min

3: benzene / Irradiation

With sodium azide; chloroformic acid ethyl ester; magnesium; triethylamine; In benzene;

DOI:10.1021/ja00221a032

upstream raw materials:

4-bromo-4'-acetylbiphenyl

ethylene glycol

Downstream raw materials:

4-acetyl-4'-biphenylcarboxylic acid

N-(cyclohexyl)-4-acetyl-4'-biphenylcarboxylic acid amide

1-[4'-((2R,3R)-2-Isopropyl-3-methyl-aziridine-1-carbonyl)-biphenyl-4-yl]-ethanone

1-[4'-((2R,3S)-2-Isopropyl-3-methyl-aziridine-1-carbonyl)-biphenyl-4-yl]-ethanone

Refernces