Imidazo(1,2-a)pyridine-6-carboxylic acid, 3-(2-(dimethylamino)-2-oxoethyl)-2-(4-methylphenyl)-

Base Information

• Chemical Name: Imidazo(1,2-a)pyridine-6-carboxylic acid, 3-(2-(dimethylamino)-2-oxoethyl)-2-(4-methylphenyl)-
• CAS No.: 109461-15-6
• Molecular Formula: C₁₉H₁₉N₃O₃
• Molecular Weight: 337.378
• UNII: 9XFN6PR11W
• DSSTox Substance ID: DTXSID80148939
• Nikkaji Number: J516.001D
• Wikidata: Q27273349
• Mol file: 109461-15-6.mol

Synonyms:109461-15-6;Zolpidem 6-Carboxylic Acid;3-[2-(Dimethylamino)-2-oxoethyl]-2-(4-methylphenyl)imidazo[1,2-a]pyridine-6-carboxylic Acid;Imidazo(1,2-a)pyridine-6-carboxylic acid, 3-(2-(dimethylamino)-2-oxoethyl)-2-(4-methylphenyl)-;SL-84.0853;SL 84.0853;9XFN6PR11W;Imidazo[1,2-a]pyridine-6-carboxylicacid, 3-[2-(dimethylamino)-2-oxoethyl]-2-(4-methylphenyl)-;3-(2-(Dimethylamino)-2-oxoethyl)-2-(p-tolyl)imidazo[1,2-a]pyridine-6-carboxylic acid;3-[(DIMETHYLCARBAMOYL)METHYL]-2-(4-METHYLPHENYL)IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLIC ACID;UNII-9XFN6PR11W;RFUGIBAONXDHRM-UHFFFAOYSA-N;Zolpidem-M 2;SCHEMBL2312485;DTXSID80148939;BCP34186;AKOS030254536;Zolpidem carboxylic acid metabolite (M2);A903988;Q27273349;3-dimethylcarbamoylmethyl-2-(4-tolyl)imidazo[1,2-a]pyridine-6-carboxylic acid

Chemical Property of Imidazo(1,2-a)pyridine-6-carboxylic acid, 3-(2-(dimethylamino)-2-oxoethyl)-2-(4-methylphenyl)-

Chemical Property:

• Melting Point: 170-172?C
• PSA: 74.91000
• LogP: 2.63860
• Storage Temp.: -20°C Freezer
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 337.14264148
• Heavy Atom Count: 25
• Complexity: 502

Purity/Quality:

97% ^*data from raw suppliers

Zolpidem6-CarboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)C2=C(N3C=C(C=CC3=N2)C(=O)O)CC(=O)N(C)C
• Uses: A major metabolite of Zolpidem. A major metabolite of Zolpidem

Technology Process of Imidazo(1,2-a)pyridine-6-carboxylic acid, 3-(2-(dimethylamino)-2-oxoethyl)-2-(4-methylphenyl)-

There total 1 articles about Imidazo(1,2-a)pyridine-6-carboxylic acid, 3-(2-(dimethylamino)-2-oxoethyl)-2-(4-methylphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

methyl 3-dimethylcarbamoylmethyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-6-carboxylate (917252-81-4) → 3-dimethylcarbamoylmethyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-6-carboxylic acid (109461-15-6)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 18h;

DOI:10.1248/cpb.54.1318

upstream raw materials:

methyl 3-dimethylcarbamoylmethyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-6-carboxylate

Refernces