ALPHA-BROMOPHENYLACETYL CHLORIDE

Base Information

• Chemical Name: ALPHA-BROMOPHENYLACETYL CHLORIDE
• CAS No.: 19078-72-9
• Molecular Formula: C8H6 Br Cl O
• Molecular Weight: 233.492
• Hs Code.: 2916399090
• Mol file: 19078-72-9.mol

Synonyms:Acetylchloride, bromophenyl- (6CI,8CI); 2-Bromo-2-phenylacetyl chloride; a-Bromobenzeneacetyl chloride; a-Bromophenylacetyl chloride

Chemical Property of ALPHA-BROMOPHENYLACETYL CHLORIDE

Chemical Property:

• PSA: 17.07000
• LogP: 2.88800
• Storage Temp.: 2-8°C

Purity/Quality:

98.5% ^*data from raw suppliers

α-Bromophenylacetyl chloride technical, 80% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ALPHA-BROMOPHENYLACETYL CHLORIDE

There total 11 articles about ALPHA-BROMOPHENYLACETYL CHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-bromophenylacetic acid (4870-65-9,31302-84-8) → bromo(phenyl)acetyl chloride (19078-72-9)

Guidance literature:

With thionyl chloride; In tetrachloromethane; at 65 ℃; for 0.5h;

DOI:10.3987/COM-02-9453

Reference yield: 99.0%

phenylacetyl chloride (103-80-0) → bromo(phenyl)acetyl chloride (19078-72-9)

Guidance literature:

With bromine; In tetrachloromethane; for 8h; Heating;

DOI:10.1021/jo00350a014

Reference yield: 98.0%

2-(4-bromophenyl)acetyl chloride (37859-24-8) + [2-(3-Methoxy-phenyl)-ethyl]-phenyl-amine (51009-27-9) → 2-(4-bromophenyl)-N-{2-(3-methoxyphenyl)ethyl}-N-phenylacetamide (295318-80-8) + bromo(phenyl)acetyl chloride (19078-72-9)

Guidance literature:

In ethyl acetate;

upstream raw materials:

phenylacetic acid

2-bromophenylacetic acid

phenylacetyl chloride

2-(4-bromophenyl)acetyl chloride

Downstream raw materials:

ethyl 2-phenyl-2-bromoacetate

2-bromo-2-phenylethanamide

α-bromo-benzyl isocyanate

(+/-)-bromo-phenyl-acetic acid isopropyl ester

Refernces

• 1、 Kolev, Tsonko,Preut, Hans,Koniczek, Lothar,Bleckmann, Paul,Juchnovski, Ivan,Mladenova, Margarita. "L-(+)-α-Bromobenzeneacetic Acid (-)-Menthyl Ester". . p. 1634 - 1636. Retrieved 1995.
• 2、 Zhao, Xiaopeng,Liang, Siyu,Fan, Xing,Yang, Tonghao,Yu, Wei. "Iron-Catalyzed Intramolecular C-H Amination of α-Azidyl Amides". supporting information. p. 1559 - 1563. Retrieved 2019/03/20.
• 3、 Xue, Xiaoqian,Zhang, Yan,Wang, Chao,Zhang, Maofeng,Xiang, Qiuping,Wang, Junjian,Wang, Anhui,Li, Chenchang,Zhang, Cheng,Zou, Lingjiao,Wang, Rui,Wu, Shuang,Lu, Yongzhi,Chen, Hongwu,Ding, Ke,Li, Guohui,Xu, Yong. "Benzoxazinone-containing 3,5-dimethylisoxazole derivatives as BET bromodomain inhibitors for treatment of castration-resistant prostate cancer". . p. 542 - 559. Retrieved 2018/05/24.