Prolylhydroxyproline

Base Information

• Chemical Name: Prolylhydroxyproline
• CAS No.: 18684-24-7
• Molecular Formula: C₁₀H₁₆N₂O₄
• Molecular Weight: 228.248
• Hs Code.: 2933990090
• Metabolomics Workbench ID: 38998
• Nikkaji Number: J666.108D
• Wikidata: Q27105024
• Mol file: 18684-24-7.mol

Synonyms:H-Pro-Hyp-OH;18684-24-7;Prolylhydroxyproline;Pro-Hyp;Pro-Hyp-OH;L-Prolyl-L-hydroxyproline;(2S,4R)-1-(L-prolyl)-4-hydroxypyrrolidine-2-carboxylic acid;(2S,4R)-4-hydroxy-1-((S)-pyrrolidine-2-carbonyl)pyrrolidine-2-carboxylic acid;DIPEPTIDE-6;proline-hydroxyproline;L-Pro-L-Hyp;SCHEMBL230501;4-hydroxy-1-L-prolyl-Proline;CHEBI:74767;L-4-hydroxy-1-L-prolyl-Proline;(2S,4R)-4-hydroxy-1-[(2S)-pyrrolidine-2-carbonyl]pyrrolidine-2-carboxylic acid;ONPXCLZMBSJLSP-CSMHCCOUSA-N;trans-4-hydroxy-1-L-prolyl-Proline;MFCD00037349;(4R)-L-prolyl-4-hydroxy-L-Proline;L-prolyl-(4R)-4-hydroxy-L-proline;AKOS013155264;CS-0449010;Q27105024;(2S,4R)-4-hydroxy-1-{[(2S)-pyrrolidin-2-yl]carbonyl}pyrrolidine-2-carboxylic acid

Chemical Property of Prolylhydroxyproline

Chemical Property:

• Refractive Index: 1.586
• Boiling Point: 513.456 °C at 760 mmHg
• Flash Point: 264.329 °C
• PSA: 89.87000
• Density: 1.417 g/cm³
• LogP: -0.94850
• Storage Temp.: -15°C
• XLogP3: -3.3
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 228.11100700
• Heavy Atom Count: 16
• Complexity: 307

Purity/Quality:

99% ^*data from raw suppliers

Pro-Hyp-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(NC1)C(=O)N2CC(CC2C(=O)O)O
• Isomeric SMILES: C1C[C@H](NC1)C(=O)N2C[C@@H](C[C@H]2C(=O)O)O

Technology Process of Prolylhydroxyproline

There total 3 articles about Prolylhydroxyproline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Cbz-Pro-Hyp-OH (55878-58-5) → Pro-Hyp (18684-24-7)

Guidance literature:

With methanol; palladium; acetic acid; Hydrogenation;

Reference yield:

Gly-Pro-Hyp (2239-67-0) → Pro-Hyp (18684-24-7)

Guidance literature:

With pig kidney aminopeptidase P; manganese(ll) chloride; at 37 ℃; Enzyme kinetics;

DOI:10.1016/0006-2952(96)00180-3

Reference yield:

→ Pro-Hyp (18684-24-7)

Guidance literature:

upstream raw materials:

Cbz-Pro-Hyp-OH

Gly-Pro-Hyp

Refernces

• 1、 Lloyd, Georgina S.,Hryszko, John,Hooper, Nigel M.,Turner, Anthony J.. "Inhibition and metal ion activation of pig kidney aminopeptidase P. Dependence on nature of substrate". . p. 229 - 236. Retrieved 2007/10/03.