1-(2-((1-ethoxycarbonyloxyethoxycarbonyl)methylcarbamoyl)-3-phenylpropyldisulfanylmethyl)-3-methylsulfanylpropyl ammonium trifluoroacetate

Base Information

• Chemical Name: 1-(2-((1-ethoxycarbonyloxyethoxycarbonyl)methylcarbamoyl)-3-phenylpropyldisulfanylmethyl)-3-methylsulfanylpropyl ammonium trifluoroacetate
• CAS No.: 935481-41-7
• Molecular Formula: C₂HF₃O₂*C₂₂H₃₄N₂O₆S₃
• Molecular Weight: 632.744
• Mol file: 935481-41-7.mol

Synonyms:1-(2-((1-ethoxycarbonyloxyethoxycarbonyl)methylcarbamoyl)-3-phenylpropyldisulfanylmethyl)-3-methylsulfanylpropyl ammonium trifluoroacetate

Chemical Property of 1-(2-((1-ethoxycarbonyloxyethoxycarbonyl)methylcarbamoyl)-3-phenylpropyldisulfanylmethyl)-3-methylsulfanylpropyl ammonium trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-((1-ethoxycarbonyloxyethoxycarbonyl)methylcarbamoyl)-3-phenylpropyldisulfanylmethyl)-3-methylsulfanylpropyl ammonium trifluoroacetate

There total 13 articles about 1-(2-((1-ethoxycarbonyloxyethoxycarbonyl)methylcarbamoyl)-3-phenylpropyldisulfanylmethyl)-3-methylsulfanylpropyl ammonium trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.5%

→ 1-(2-((1-ethoxycarbonyloxyethoxycarbonyl)methylcarbamoyl)-3-phenylpropyldisulfanylmethyl)-3-methylsulfanylpropyl ammonium trifluoroacetate (935481-41-7)

Guidance literature:

Reference yield:

C27H42N2O8S3 (1196260-69-1) + trifluoroacetic acid (76-05-1) → 1-(2-((1-ethoxycarbonyloxyethoxycarbonyl)methylcarbamoyl)-3-phenylpropyldisulfanylmethyl)-3-methylsulfanylpropyl ammonium trifluoroacetate (935481-41-7)

Guidance literature:

C₂₇H₄₂N₂O₈S₃; With formic acid; at 20 ℃; for 1h;

trifluoroacetic acid; In water; acetonitrile;

DOI:10.1021/jm500602h

Reference yield:

1-(ethoxycarbonyloxy)ethyl 2-aminoacetate trifluoroacetate (935481-30-4) → 1-(2-((1-ethoxycarbonyloxyethoxycarbonyl)methylcarbamoyl)-3-phenylpropyldisulfanylmethyl)-3-methylsulfanylpropyl ammonium trifluoroacetate (935481-41-7)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0.33 h / 20 °C

2: formic acid / 1 h / 20 °C

With formic acid; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

DOI:10.1021/jm500602h

upstream raw materials:

1-(ethoxycarbonyloxy)ethyl 2-aminoacetate trifluoroacetate

C₁₂H₂₁NO₇

1-Chloroethyl ethyl carbonate

Thioacetic acid S-((S)-2-tert-butoxycarbonylamino-4-methylsulfanyl-butyl) ester

Downstream raw materials:

1(S)-(2-((1-ethoxycarbonyloxyethoxycarbonylmethyl)carbamoyl)-3-phenylpropyldisulfanylmethyl)-3-methylsulfanylpropylammonium dihydrophosphate

Refernces

• 1、 -. "AMINOACID DERIVATIVES CONTAINING A DISULFANYL GROUP IN THE FORM OF MIXED DISULFANYL AND AMINOPEPTIDASE N INHIBITORS". Page/Page column 13. . Retrieved 2009/01/24.