4-(2-PYRIDYL)ANILINE

Base Information

• Chemical Name: 4-(2-PYRIDYL)ANILINE
• CAS No.: 18471-73-3
• Molecular Formula: C11H10N2
• Molecular Weight: 170.214
• Hs Code.: 2933399090
• Mol file: 18471-73-3.mol

Synonyms:Pyridine,2-(p-aminophenyl)- (6CI,7CI,8CI);2-(4-Aminophenyl)pyridine;2-(p-Aminophenyl)pyridine;4-(2-Pyridyl)aminobenzene;4-(2-Pyridyl)aniline;4-(Pyridin-2-yl)aniline;AC1LA0MV;CID459518;

Chemical Property of 4-(2-PYRIDYL)ANILINE

Chemical Property:

• Vapor Pressure: 0.000272mmHg at 25°C
• Melting Point: 95 °C
• Refractive Index: 1.625
• Boiling Point: 322.8 °C at 760 mmHg
• PKA: 5.72±0.25(Predicted)
• Flash Point: 175.1 °C
• PSA: 38.91000
• Density: 1.133 g/cm³
• LogP: 2.91200

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-(2-Pyridyl)aniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(2-PYRIDYL)ANILINE

There total 20 articles about 4-(2-PYRIDYL)ANILINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

p-aminoiodobenzene (540-37-4) + pyridin-2-ylzinc(II) bromide → 4-(pyridin-2-yl)aniline (18471-73-3)

Guidance literature:

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; In tetrahydrofuran; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.tetlet.2009.09.160

Reference yield: 89.0%

4-bromo-aniline (106-40-1) + pyridin-2-ylzinc(II) bromide → 4-(pyridin-2-yl)aniline (18471-73-3)

Guidance literature:

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; In tetrahydrofuran; for 24h; Inert atmosphere; Reflux;

DOI:10.1016/j.tet.2010.02.061

Reference yield: 87.0%

2-(4-nitrophenyl)pyridine (4282-47-7) → 4-(pyridin-2-yl)aniline (18471-73-3)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 18h; under 760.051 Torr;

DOI:10.1016/j.ejmech.2015.03.025

upstream raw materials:

2-(4-nitrophenyl)pyridine

2-chloropyridine

4-bromo-aniline

p-aminoiodobenzene

Downstream raw materials:

4-(2-pyridyl)phenylhydrazone ethyl pyruvate syn-isomer

4-(2-pyridyl)phenylhydrazone ethyl pyruvate anti-isomer

7-(4-methylphenyl)-N-[4-(pyridin-2-yl)phenyl]-2,3-dihydro-1-benzoxepine-4-carboxamide

Refernces

• 1、 Li, Yuchao,Li, Xuezhao,Li, Lili,Xiao, Bing,Wu, Jinguo,Li, Hechuan,Li, Danyang,He, Cheng. "Phenoxazine-based supramolecular tetrahedron as biomimetic lectin for glucosamine recognition". supporting information. p. 735 - 739. Retrieved 2020/07/30.
• 2、 -. "Novel hydrazone derivatives comprising aryl or heteroaryl group substituted at terminal amine and use thereof". Paragraph 0325; 0327; 0328; 0415; 0417-0419. . Retrieved 2020/08/28.