H-D-Phe-Pna

Base Information

• Chemical Name: H-D-Phe-Pna
• CAS No.: 14235-18-8
• Molecular Formula: C15H15 N3 O3
• Molecular Weight: 285.302
• Hs Code.: 2924299090
• DSSTox Substance ID: DTXSID70428590
• Wikidata: Q82241415
• Mol file: 14235-18-8.mol

Synonyms:H-D-Phe-Pna;14235-18-8;(2R)-2-amino-N-(4-nitrophenyl)-3-phenylpropanamide;D-Phenylalanine 4-nitroanilide;DTXSID70428590;MFCD00077153;N-(4-Nitrophenyl)-D-phenylalaninamide;AS-46825;F10634;A885191

Chemical Property of H-D-Phe-Pna

Chemical Property:

• PSA: 100.94000
• LogP: 3.39980
• Storage Temp.: Store at 0°C
• XLogP3: 2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 285.11134135
• Heavy Atom Count: 21
• Complexity: 356

Purity/Quality:

99% ^*data from raw suppliers

D-Phenylalanine4-Nitroanilide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CC(C(=O)NC2=CC=C(C=C2)[N+](=O)[O-])N
• Isomeric SMILES: C1=CC=C(C=C1)C[C@H](C(=O)NC2=CC=C(C=C2)[N+](=O)[O-])N
• Uses: D-Phenylalanine 4-Nitroanilide is a chromogenic substrate.

Technology Process of H-D-Phe-Pna

There total 16 articles about H-D-Phe-Pna which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

C20H23N3O5 → H-D-Phe-pNA (14235-18-8)

Guidance literature:

C₂₀H₂₃N₃O₅; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 4h;

With sodium hydrogencarbonate; at 20 ℃; for 1h;

Reference yield: 94.0%

L-Phenylalanine amide (5241-58-7) + para-nitrophenyl bromide (586-78-7) → L-phenylalanine-p-nitroanilide (2360-97-6,14235-17-7,14235-18-8,97471-44-8)

Guidance literature:

With copper(l) iodide; potassium carbonate; In toluene; at 110 ℃; for 24h; Inert atmosphere; Sealed tube;

DOI:10.1002/adsc.201200752

Reference yield: 87.0%

N-(1,1-dimethylethoxycarbonyl)-L-phenylalanine N-(4-nitrophenyl)amide (97885-48-8) → L-phenylalanine-p-nitroanilide (2360-97-6,14235-17-7,14235-18-8,97471-44-8)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

DOI:10.3390/molecules26020482

upstream raw materials:

benzyl (S)-(1-((4-nitrophenyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate

H-Ala-Ala-Phe-p-nirtoanilide

N-(1,1-dimethylethoxycarbonyl)-L-phenylalanine N-(4-nitrophenyl)amide

N-tert-butoxycarbonyl-L-phenylalanine

Downstream raw materials:

L-phenylalanine

4-nitro-aniline

Boc-L-Tyr-D-Leu-L-Phe-pNA

Suc-L-Tyr-D-Leu-L-Phe-pNA

Refernces

• 1、 Kania, Joanna,Gillner, Danuta M.. "Characterisation of the aminopeptidase from non-germinated winter rape (Brassica napus L.) seeds". . p. 180 - 186. Retrieved 2016/04/19.
• 2、 Matsuo, Takashi,Imai, Chie,Yoshida, Takefumi,Saito, Takashi,Hayashi, Takashi,Hirota, Shun. "Creation of an artificial metalloprotein with a Hoveyda-Grubbs catalyst moiety through the intrinsic inhibition mechanism of α-chymotrypsin". supporting information; body text. p. 1662 - 1664. Retrieved 2012/03/27.