2-phenyl-3-(4'-[N-(4''-aminophenyl)carbamoyl]-phenyl)-quinazoline-4(3H)-one-6-sulphonic acid

Base Information

• Chemical Name: 2-phenyl-3-(4'-[N-(4''-aminophenyl)carbamoyl]-phenyl)-quinazoline-4(3H)-one-6-sulphonic acid
• CAS No.: 1303968-87-7
• Molecular Formula: C₂₇H₂₀N₄O₅S
• Molecular Weight: 512.546
• Mol file: 1303968-87-7.mol

Synonyms:2-phenyl-3-(4'-[N-(4''-aminophenyl)carbamoyl]-phenyl)-quinazoline-4(3H)-one-6-sulphonic acid

Chemical Property of 2-phenyl-3-(4'-[N-(4''-aminophenyl)carbamoyl]-phenyl)-quinazoline-4(3H)-one-6-sulphonic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-phenyl-3-(4'-[N-(4''-aminophenyl)carbamoyl]-phenyl)-quinazoline-4(3H)-one-6-sulphonic acid

There total 7 articles about 2-phenyl-3-(4'-[N-(4''-aminophenyl)carbamoyl]-phenyl)-quinazoline-4(3H)-one-6-sulphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-phenyl-4-oxo-3,1-benzoxazine-6-sulphonic acid (1221348-26-0) + 4,4'-diaminobenzanilide (785-30-8) → 2-phenyl-3-(4'-[N-(4''-aminophenyl)carbamoyl]-phenyl)-quinazoline-4(3H)-one-6-sulphonic acid (1303968-87-7)

Guidance literature:

2-phenyl-4-oxo-3,1-benzoxazine-6-sulphonic acid; 4,4'-diaminobenzanilide; With pyridine; for 6h; Reflux;

With hydrogenchloride; In water; at 20 ℃;

DOI:10.2298/JSC090225021P

Reference yield:

4,4'-dinitrobenzanilide (6333-15-9) → 2-phenyl-3-(4'-[N-(4''-aminophenyl)carbamoyl]-phenyl)-quinazoline-4(3H)-one-6-sulphonic acid (1303968-87-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride; iron / water / 2 h / 95 - 98 °C

2.1: pyridine / 6 h / Reflux

2.2: 20 °C

With pyridine; hydrogenchloride; iron; In water;

DOI:10.2298/JSC090225021P

Reference yield:

4-nitro-aniline (100-01-6,104810-17-5) → 2-phenyl-3-(4'-[N-(4''-aminophenyl)carbamoyl]-phenyl)-quinazoline-4(3H)-one-6-sulphonic acid (1303968-87-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / chlorobenzene / 4.5 h / 90 - 95 °C

2.1: hydrogenchloride; iron / water / 2 h / 95 - 98 °C

3.1: pyridine / 6 h / Reflux

3.2: 20 °C

With pyridine; hydrogenchloride; iron; triethylamine; In water; chlorobenzene;

DOI:10.2298/JSC090225021P

upstream raw materials:

2-phenyl-4-oxo-3,1-benzoxazine-6-sulphonic acid

4,4'-diaminobenzanilide

4,4'-dinitrobenzanilide

2-amino-5-sulfo-benzoic acid

Refernces